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首页> 外文期刊>Trends in Plant Science >Believe it or not, QTLs are accurate!
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Believe it or not, QTLs are accurate!

机译：信不信由你，QTL是准确的！

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摘要

It is generally believed that mapping quantitative trait loci (QTLs) does not accurately position genes underlying polygenic traits on the genome, which limits the application of QTL analysis in marker-assisted selection and gene discovery. However, now that a few plant QTLs have been cloned or accurately tagged, it appears that they might be accurate to within 2cM or less. This means that there will be circumstances when map-based cloning using only original mapping data would be a realistic option that avoids time-consuming and expensive fine mapping. Acceptance of this view would enhance the value of past and future mapping experiments, particularly those revealing small and environmentally sensitive QTLs that are often considered intractable at the molecular level.
机译：通常认为，定位定量性状基因座（QTL）不能准确定位基因组中多基因性状的潜在基因，这限制了QTL分析在标记辅助选择和基因发现中的应用。但是，现在已经克隆了一些植物QTL或对其进行了精确标记，看来它们可能在2cM或更小范围内是准确的。这意味着在某些情况下，仅使用原始映射数据进行基于映射的克隆将是一个现实的选择，可以避免耗时且昂贵的精细映射。接受此观点将提高过去和将来的作图实验的价值，尤其是那些揭示了小型且对环境敏感的QTL的实验，这些分子通常被认为在分子水平上难以处理。

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