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首页> 外文期刊>Trends in Plant Science >Phytochrome signaling: solving the Gordian knot with microbial relatives
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Phytochrome signaling: solving the Gordian knot with microbial relatives

机译：植物色素信号传导：与微生物亲戚解决高迪氏结

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摘要

Phytochromes encompass a diverse collection of biliproteins that regulate numerous photoresponses in plants and microorganisms. Whereas the plant versions have proven experimentally intractable for structural studies, the microbial forms have recently provided important insights into how these photoreceptors work at the atomic level. Here, we review the current understanding of these microbial phytochromes, which shows that they have a modular dimeric architecture that propagates light-driven rotation of the bilin to distal contacts between adjacent signal output domains. Surprising features underpinning this signaling include: a deeply buried chromophore; a knot and hairpin loop that stabilizes the photosensing domain; and an extended helical spine that translates conformational changes in the photosensing domain to the output domain. Conservation within the superfamily both in modular construction and sequence strongly suggests that higher plant phytochromes work similarly as light-regulated toggle switches.
机译：植物色素包含多种多样的胆蛋白，可调节植物和微生物中的许多光响应。尽管已经证明植物版本对于结构研究在实验上是棘手的，但微生物形式最近为这些感光体如何在原子水平上起作用提供了重要的见识。在这里，我们回顾了对这些微生物植物色素的当前了解，这表明它们具有模块化的二聚体结构，可将光驱动的胆红素旋转传播到相邻信号输出域之间的远侧触点。支持该信号的令人惊讶的特征包括：深度掩埋的生色团;结和发夹环使光敏域稳定;以及一个延伸的螺旋形脊柱，可将光敏域中的构象变化转化为输出域。超家族内在模块构建和序列上的保护都强烈表明，高等植物的植物色素的作用与光调节拨动开关相似。

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