...
首页> 外文期刊>Trends in Plant Science >MicroRNA misregulation: an overlooked factor generating somaclonal variation?
【24h】

MicroRNA misregulation: an overlooked factor generating somaclonal variation?

机译:MicroRNA调节异常:产生体细胞克隆变异的一个被忽略的因素?

获取原文
获取原文并翻译 | 示例
           

摘要

Somaclonal variation is an important phenomenon that can be observed at high levels in plant tissue culture. Although known to science since plant cell culture techniques were first developed, its origins remain mysterious. Here, we propose that misregulation of microRNAs and small RNA pathways can make a significant contribution to the phenomenon. For many reasons, microRNAs and related small RNAs appear ideal candidates. Their mode of action gives them disproportionate influence over the transcriptome, proteome and epigenome. They regulate important developmental and physiological events such as meristem formation, phase changes and hormone responses. However, the genomic locations of microRNA genes and their unique biogenesis might make them unusually susceptible to aberrant regulation in vitro.
机译:体细胞克隆变异是一种重要现象,可以在植物组织培养物中高水平观察到。尽管自从植物细胞培养技术被首次开发以来就已为科学所知,但其起源仍然是神秘的。在这里,我们建议微RNA和小RNA通路的失调可以对这一现象做出重大贡献。由于许多原因,microRNA和相关的小RNA似乎是理想的候选对象。他们的作用方式使他们对转录组,蛋白质组和表观基因组的影响不成比例。它们调节重要的发育和生理事件,例如分生组织形成,相变和激素反应。然而,microRNA基因的基因组位置及其独特的生物发生可能使它们异常受体外异常调节的影响。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号