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Do plants have more genes than humans? Yes, when it comes to ABC proteins

机译:植物比人类有更多的基因吗?是的,当涉及到ABC蛋白时

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Joachim Messing in his recent 'Comment' discussed the remarkable similarity in gene count between the human and Arabidopsis thaliana genomes. No one knows why the number of open-readingframes (ORFs) in theArabidopsis genome (25 500) is only slightly less than that estimated for the human genome (31500) - specifically, how humans can get by with so few genes - but we can answer Messing's opening question 'Do plants have more genes than humans?' in the affirmative in at least some cases. The ATP-binding cassette (ABC) proteins are a case in point, many of which are modularly constructed membrane proteins containing idiotypic nucleotidebinding folds (NBFs). By compiling the first complete inventory of the ABC protein superfamily fromArabidopsis (http://www.arabidopsisabc.net) - the first complete inventory of ABC proteins from any multicellular organism - we have determined that the genome of this plant encodes 129 ABC proteins, which fall into 13 subfamilies (Fig. 1). This gene count far outstrips those for the human genome and for any other animal genome sequenced to date. The human genome is estimated to encode a mere 51ABC proteins (http://www. humanabc.org); those of Caenorhabditis elegans (19 000 ORFs; http://www.proteome.com/databases/WormPD/WormPDsearch-long.html) and Drosophila melanogaster (13 600 ORFs; http://fiybase.bio.indiana.edu/) only 58 and 55, respectively.
机译:约阿希姆·梅辛(Joachim Messing)在他最近的《评论》中讨论了人类和拟南芥基因组在基因计数上的显着相似性。没有人知道为什么拟南芥基因组中的开放阅读框(ORF)数量(25 500)仅比人类基因组估计的开放阅读框(31500)少-特别是人类如何通过如此少的基因就可以生存-但我们可以回答Messing的开放性问题“植物比人类有更多的基因吗?”至少在某些情况下是肯定的。 ATP结合盒(ABC)蛋白就是一个很好的例子,其中许多是包含特异核苷酸结合折叠(NBF)的模块化构建的膜蛋白。通过汇总来自拟南芥(Arabidopsis)(http://www.arabidopsisabc.net)的ABC蛋白质超家族的第一个完整清单-来自任何多细胞生物的ABC蛋白质的第一个完整清单-我们确定该植物的基因组编码129个ABC蛋白质,分为13个亚科(图1)。该基因的数量远远超过了人类基因组和迄今测序的任何其他动物基因组的数量。据估计,人类基因组仅编码51ABC蛋白(http://www.humanabc.org)。秀丽隐杆线虫(19000 ORF; http://www.proteome.com/databases/WormPD/WormPDsearch-long.html)和果蝇(13600 ORF; http://fiybase.bio.indiana.edu/)分别只有58和55。

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