Towards revealing the functions of all genes in plants

Rhee Seung Yon; Mutwil Marek

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Towards revealing the functions of all genes in plants

机译：揭示植物中所有基因的功能

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The great recent progress made in identifying the molecular parts lists of organisms revealed the paucity of our understanding of what most of the parts do. In this review, we introduce computational and statistical approaches and omics data used for inferring gene function in plants, with an emphasis on network-based inference. We also discuss caveats associated with network-based function predictions such as performance assessment, annotation propagation, the guilt-by-association concept, and the meaning of hubs. Finally, we note the current limitations and possible future directions such as the need for gold standard data from several species, unified access to data and tools, quantitative comparison of data and tool quality, and high-throughput experimental validation platforms for systematic gene function elucidation in plants.

机译：最近在确定生物分子部分清单方面取得的巨大进展表明，我们对大多数部分的作用了解不足。在这篇综述中，我们介绍了用于推断植物基因功能的计算和统计方法以及组学数据，重点是基于网络的推断。我们还将讨论与基于网络的功能预测相关的警告，例如性能评估，注释传播，内的关联概念以及集线器的含义。最后，我们注意到当前的局限性和可能的未来方向，例如需要来自多个物种的金标准数据，对数据和工具的统一访问，对数据和工具质量的定量比较以及用于系统基因功能阐明的高通量实验验证平台在植物中。

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《Trends in Plant Science》 |2014年第4期|共10页
作者
Rhee Seung Yon; Mutwil Marek;
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原文格式 PDF
正文语种 eng
中图分类植物学;
关键词
function prediction; omics; big data; networks; co-expression; co-function;

机译：功能预测;组学;大数据;网络;协同表达;协同功能;

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专利

1. Towards revealing the functions of all genes in plants [J] . Rhee Seung Yon, Mutwil Marek Trends in Plant Science . 2014,第4期

机译：揭示植物中所有基因的功能
2. RNAi for revealing and engineering plant gene functions [J] . Ian Small Current Opinion in Biotechnology . 2007,第2期

机译：RNAi用于揭示和工程化植物基因功能
3. Modes of antifungal action and in planta functions of plant defensins and defensin-like peptides. (Special Issue: Revealing diverse modes of action and biological roles of antifungal peptides.) [J] . Coninck B. de, Cammue B. P. A., Thevissen K. Fungal Biology Reviews . 2013,第4期

机译：植物防御素和防御素样肽的抗真菌作用模式和在植物中的功能。（特刊：揭示抗真菌肽的多种作用方式和生物学作用。）
4. Revealing the Functions of Glycosylation Genes in Breast Cancer Cell Brain Metastasis with Gene Silencing Coupled to LC-MS/MS Glycomics [C] . Wenjing Peng, Shiyue Zhou, Xue Dong, ASMS Conference on Mass Spectrometry and Allied Topics . 2016

机译：揭示糖基化基因在乳腺癌细胞脑转移中的功能与LC-MS / MS族的基因沉默
5. Rethinking the industrial landscape---Revealing the curative potential of genetically modified plants. [D] . Horton, Susannah. 2012

机译：重新思考工业格局-揭示转基因植物的治疗潜力。
6. Rapid plant regeneration in industrially important Curcuma zedoaria revealing genetic and biochemical fidelity of the regenerants [O] . Sudipta Jena, Asit Ray, Ambika Sahoo, 2020

机译：在工业上的植物再生快速植物再生揭示了再生剂的遗传和生化保真度
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Towards revealing the functions of all genes in plants

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