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首页> 外文期刊>Tumori. >Relationship between the shape and size of radiofrequency induced thermal lesions and hepatic vascularization.
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Relationship between the shape and size of radiofrequency induced thermal lesions and hepatic vascularization.

机译：射频诱发的热损伤的形状和大小与肝血管形成之间的关系。

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AIMS AND BACKGROUND: The aim of this study was to evaluate the relationship between hepatic vascularisation and the final size and shape of radiofrequency (RF) induced thermal lesions. METHODS: Series of four RF thermal lesions were created in explanted calf livers and in pig livers maintaining the following experimental conditions throughout the procedure: normal hepatic perfusion, occlusion of the hepatic artery, occlusion of the portal vein, occlusion of both hepatic artery and portal vein (Pringle maneuver) and subtotal occlusion of the hepatic veins. A 14G expandable needle electrode was used to make the thermal lesions. Each lesion was created applying predetermined temperatures ranging between 95 and 115 degrees C and an exposure time of 20 minutes. RESULTS: Occlusion of the hepatic artery during the RF procedure resulted in moderate and not significant increases in thermal lesion diameter compared with those obtained in normally perfused liver (3.0 +/- 0.4 cm vs 3.0 +/- 0.2 cm), while occlusion of the portal vein resulted in larger lesion diameters (3.5 +/- 0.3 cm). In both these cases the diameters of the thermal lesions were smaller than those obtained in explanted calf liver (4.0 +/- 0.3 cm) and their shape showed peripheral irregularities. Thermal lesions larger than those seen in normally perfused liver and equaling those observed in explanted calf liver were created both during the Pringle maneuver (4.0 +/- 0.2 cm) and after subtotal occlusion of the hepatic veins (4.0 +/- 0.3 cm). In both these cases the thermal lesions were regular in shape. CONCLUSIONS: Occlusion of the blood flow during the RF procedure avoids heat loss by convection, resulting in the creation of larger thermal lesions than those obtained in normally vascularized liver using the same electrode, temperatures and exposure time. This technique could therefore be employed in humans to destroy large hepatic tumor nodules.
机译：目的和背景：本研究的目的是评估肝血管形成与射频（RF）诱导的热损伤的最终大小和形状之间的关系。方法：在移植的小腿肝脏和猪肝脏中产生一系列四个射频热损伤，在整个过程中均保持以下实验条件：正常肝灌注，肝动脉闭塞，门静脉闭塞，肝动脉和门静脉闭塞静脉（Pringle动作）和肝静脉次全阻塞。使用14G的可扩展针状电极进行热损伤。使用介于95到115摄氏度之间的预定温度和20分钟的暴露时间来创建每个病变。结果：与常规灌注肝相比，RF手术中肝动脉闭塞导致热损伤直径适度增加，但无明显增加（3.0 +/- 0.4 cm vs 3.0 +/- 0.2 cm），而门静脉导致更大的病变直径（3.5 +/- 0.3厘米）。在这两种情况下，热损伤的直径均小于移植小牛肝脏的直径（4.0 +/- 0.3 cm），并且它们的形状显示出周围的不规则性。在普林格尔（Pringle）手术（4.0 +/- 0.2 cm）以及肝静脉次全闭塞（4.0 +/- 0.3 cm）期间，都产生了比正常灌注肝脏更大的热损伤，与移植后的小牛肝脏相同。在这两种情况下，热损伤的形状都是规则的。结论：RF手术中血流的阻塞避免了对流造成的热损失，与使用相同电极，温度和暴露时间的正常血管化肝脏相比，产生了更大的热损伤。因此，该技术可用于人类以破坏大的肝肿瘤结节。

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