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首页> 外文期刊>Tumori. >Expression of cathepsin D in bladder carcinoma: correlation with pathological features and serum cystatin C levels.
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Expression of cathepsin D in bladder carcinoma: correlation with pathological features and serum cystatin C levels.

机译：组织蛋白酶D在膀胱癌中的表达：与病理特征和血清胱抑素C水平的相关性。

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AIMS AND BACKGROUND: The aim of this study is to evaluate the expression of cathepsin D in primary bladder cancer and to determine its relationship with conventional pathological features and serum cystatin C levels. METHODS: The immunohistochemical cathepsin D expression and staining patterns of epithelial and stromal cells were investigated in 21 patients with primary bladder carcinoma. Serum cystatin C levels were determined by immunoturbidimetry and compared with matched controls. RESULTS: There were 7 papillary neoplasms of low malignant potential, 7 low-grade and 7 high-grade carcinomas. Six tumors were invasive. Statistical analysis showed a significant inverse relationship between cathepsin D expression of the tumor cells and tumor grade and stage (P = 0.018 and P = 0.046, respectively). Serum cystatin C levels of the controls and patients varied between 0.39 mg/L and 1.99 mg/L (P > 0.05). There was no significant relation between cathepsin D expression in tumor tissue and serum cystatin C levels. CONCLUSIONS: Loss of cathepsin D expression in bladder carcinomas may be associated with high-grade and invasive tumors. Thus, increased cathepsin D expression by tumor cells may be related to local tumor invasion at an early stage, but it seems that extracellular cystatin C is not affected by cathepsin D expression of tumor or stromal cells, and cystatin C concentrations are not directly correlated with the progression of primary bladder carcinomas.
机译：目的和背景：本研究的目的是评估组织蛋白酶D在原发性膀胱癌中的表达，并确定其与常规病理特征和血清胱抑素C水平的关系。方法：调查21例原发性膀胱癌患者的免疫组织化学组织蛋白酶D的表达及上皮和基质细胞的染色情况。通过免疫比浊法测定血清胱抑素C水平，并与匹配的对照进行比较。结果：低恶性潜能的乳头状肿瘤7例，低度恶性肿瘤7例，高度恶性肿瘤7例。六个肿瘤是浸润性的。统计分析表明，肿瘤细胞组织蛋白酶D表达与肿瘤分级和分期之间存在显着的负相关关系（分别为P = 0.018和P = 0.046）。对照组和患者的血清胱抑素C水平在0.39 mg / L和1.99 mg / L之间变化（P> 0.05）。肿瘤组织中组织蛋白酶D的表达与血清胱抑素C水平之间无显着相关性。结论：膀胱癌组织蛋白酶D表达的丧失可能与高度浸润性和浸润性肿瘤有关。因此，肿瘤细胞中组织蛋白酶D表达的增加可能与早期局部肿瘤的侵袭有关，但似乎细胞外半胱氨酸蛋白酶抑制剂C不受肿瘤或基质细胞组织蛋白酶D表达的影响，并且半胱氨酸蛋白酶抑制剂C的浓度与肿瘤细胞或基质细胞的表达不直接相关。原发性膀胱癌的进展。

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