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首页> 外文期刊>Tumori. >Combining independent studies of diagnostic fluorodeoxyglucose positron-emission tomography and computed tomography in mediastinal lymph node staging for non-small cell lung cancer.
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Combining independent studies of diagnostic fluorodeoxyglucose positron-emission tomography and computed tomography in mediastinal lymph node staging for non-small cell lung cancer.

机译：结合对非小细胞肺癌纵隔淋巴结分期的诊断性氟脱氧葡萄糖正电子发射断层扫描和计算机断层扫描的独立研究。

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AIMS AND BACKGROUND: A meta-analysis of diagnostic test performance was conducted to compare the results of relevant studies reporting diagnostic accuracy values for mediastinal staging in patients with non-small cell lung cancer (NSCLC). This paper deals with the two most accurate imaging techniques currently in use: positron emission tomography (PET) with FDG and computed tomography (CT). A statistical pooling method was used to perform a quantitative meta-analysis aimed at demonstrating the potential advantage of one of these two methods. METHODS: Studies in all languages published between 1998 and 2005 that examined the use of FDG-PET and CT for mediastinal staging in NSCLC patients, enrolled at least 18 participants, and provided enough data to allow calculation of sensitivity and specificity rates were considered eligible for the quantitative meta-analysis. Statistical methods to pool the overall estimates of sensitivity and specificity and to compare the discriminant power of PET and CT were discussed and used. RESULTS: Of the 13 studies included in the analysis, 12 reported greater accuracy of FDG-PET than CT in detecting mediastinal lymph node metastases. The sensitivity of FDG-PET ranged from 50% to 100%. The estimate of the overall sensitivity was 0.83% with 95% CI (0.749-0.913). Specificity ranged from 79% to 100%, with an overall estimated specificity of 0.87% with 95% CI (0.80-0.95). For CT, the sensitivity and specificity ranged from 50% to 97% and 58% to 94%, respectively; the overall estimate was 0.68% with 95% CI (0.582-0.788) and 0.76% with 95% CI (0.668-0.859). The summary receiver operating characteristic (SROC) approach was used to assess the superior diagnostic accuracy of one of the two methods. The areas under the two SROC curves were AUC(PET) = 0.909 vs. AUC(CT) = 0.794. CONCLUSIONS: Numerical and visual results of the meta-analysis of recent relevant reports agreed that FDG-PET is more accurate than CT in identifying mediastinal lymph node metastases in non-small cell lung cancer.
机译：目的和背景：进行了诊断测试性能的荟萃分析，以比较相关研究的结果，这些研究报告了非小细胞肺癌（NSCLC）患者纵隔分期的诊断准确性值。本文介绍了当前使用的两种最精确的成像技术：具有FDG的正电子发射断层扫描（PET）和计算机断层扫描（CT）。统计汇总方法用于执行定量荟萃分析，旨在证明这两种方法之一的潜在优势。方法：1998年至2005年间发表的所有语言研究，研究了在非小细胞肺癌患者中使用FDG-PET和CT进行纵隔分期的研究，至少招募了18名参与者，并提供了足够的数据以计算敏感性和特异性率被认为符合条件。定量荟萃分析。讨论并使用了统计方法，以汇总敏感性和特异性的总体估计值并比较PET和CT的判别力。结果：在分析中包括的13项研究中，有12项报道了FDG-PET在检测纵隔淋巴结转移方面的准确性高于CT。 FDG-PET的灵敏度为50％至100％。总体敏感性的估计值为0.83％，CI为95％（0.749-0.913）。特异性范围从79％到100％，总体估计特异性为0.87％，CI为95％（0.80-0.95）。对于CT，敏感性和特异性分别为50％至97％和58％至94％。 95％CI（0.582-0.788）的总体估计为0.68％，95％CI（0.668-0.859）的总体估计为0.76％。摘要接收器操作特性（SROC）方法用于评估两种方法之一的卓越诊断准确性。两条SROC曲线下的面积分别为AUC（PET）= 0.909与AUC（CT）= 0.794。结论：近期相关报道的荟萃分析的数字和视觉结果表明，FDG-PET在确定非小细胞肺癌纵隔淋巴结转移方面比CT更准确。

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