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首页> 外文期刊>Tumori. >Optical biopsy of cancer: nanotechnological aspects.
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Optical biopsy of cancer: nanotechnological aspects.

机译：癌症的光学活检：纳米技术方面。

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摘要

Naturally occurring differences in the optical properties of normal and cancerous tissue have been exploited frequently in optical detection systems. However, optical biopsy of cancer can be improved by using targeted, optically active and bright contrast agents to enhance the optical signal from disease-specific molecular markers. Nanotechnology has advanced greatly in recent years and can be applied to variety of biomedical research areas, as well as optical biopsy in clinical settings. Quantum dots (QDs) are stable, bright fluorophores that, under ideal conditions, can have high quantum yields, narrow fluorescence emission bands, high absorbency, very large effective Stokes shifts, high resistance to photobleaching, and can provide excitation of several different emission colours using a single wavelength for excitation. Optically efficient, cancer specific QDs provide a new tool to enable non-invasive visualization of disease-specific molecular and tissue changes with subcellular spatial resolution. Nanotechnology is in a unique position to transform cancer diagnostics and to produce a new generation of fluorescent markers and medical imaging techniques with higher sensitivity and precision of recognition.
机译：正常组织和癌组织的光学性质中自然发生的差异已在光学检测系统中得到了广泛利用。然而，通过使用靶向的，旋光性的和明亮的造影剂来增强来自疾病特异性分子标记的光信号，可以改善癌症的光学活检。近年来，纳米技术取得了巨大的进步，可以应用于各种生物医学研究领域以及临床环境中的光学活检。量子点（QD）是稳定的明亮荧光团，在理想条件下可以具有高量子产率，窄的荧光发射带，高吸收性，非常大的斯托克斯位移，对光致漂白的高抵抗力，并可以激发几种不同的发射颜色使用单个波长进行激发。光学有效的癌症特异性QD提供了一种新工具，可通过亚细胞空间分辨率对疾病特异性分子和组织变化进行非侵入性可视化。纳米技术在改变癌症诊断方法，生产具有更高灵敏度和识别精度的新一代荧光标记和医学成像技术方面处于独特的地位。

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