Association of gastrointestinal stromal tumor and acute myeloid leukemia preceded by myelodysplastic syndrome with refractory anemia.

Sonmez M; Arslan M; Cobanoglu U; Kavgaci H; Ozbas HM; Aydin F; Ovali E; Omay SB

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Association of gastrointestinal stromal tumor and acute myeloid leukemia preceded by myelodysplastic syndrome with refractory anemia.

机译：胃肠道间质瘤与急性髓性白血病伴有骨髓增生异常综合征伴难治性贫血。

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Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. GISTs are believed to be related to mutational activation of receptor tyrosine kinases, KIT, or platelet-derived growth factor receptor-alpha. The coexistence of GISTs with other neoplams has been extensively addressed in the literature. The most common second neoplasms are colorectal cancer, prostate cancer, and neoplasms derived from lymphoid tissue. In this case report, we describe a patient affected by GIST and acute myeloid leukemia preceded by myelodysplastic syndrome with refractory anemia. The clinicopathological characteristics of the patient are discussed and the literature is reviewed.

机译：胃肠道间质瘤（GIST）是胃肠道最常见的间质肿瘤。 GIST被认为与受体酪氨酸激酶，KIT或血小板衍生的生长因子受体-α的突变激活有关。在文献中已经广泛地论述了GIST与其他瘤形成的共存。最常见的第二肿瘤是大肠癌，前列腺癌和来自淋巴组织的肿瘤。在本病例报告中，我们描述了一名患有GIST和急性髓性白血病并伴有难治性贫血的骨髓增生异常综合症的患者。讨论了患者的临床病理特征，并复习了文献。

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来源
《Tumori.》 |2009年第2期|共3页
作者
Sonmez M; Arslan M; Cobanoglu U; Kavgaci H; Ozbas HM; Aydin F; Ovali E; Omay SB;
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正文语种 eng
中图分类肿瘤学;
关键词
Gastrointestinal stromal tumor; Myelodysplastic Syndromes; Leukemia; Myelocytic; Acute; Anemia; Refractory; receptor; *骨髓增生异常综合征; 白血病; 粒细胞; 急性; 贫血; 难治性;

机译：Gastrointestinal stromal tumor;Myelodysplastic Syndromes;Leukemia;Myelocytic;Acute;Anemia;Refractory;receptor;*骨髓增生异常综合征;白血病;粒细胞;急性;贫血;难治性;

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1. Association of gastrointestinal stromal tumor and acute myeloid leukemia preceded by myelodysplastic syndrome with refractory anemia. [J] . Sonmez M, Arslan M, Cobanoglu U, Tumori. . 2009,第2期

机译：胃肠道间质瘤与急性髓性白血病伴有骨髓增生异常综合征伴难治性贫血。
2. Twice-daily fludarabine and cytarabine combination with or without gentuzumab ozogamicin is effective in patients with relapsed/refractory acute myeloid leukemia, high-risk myelodysplastic syndrome, and blast- phase chronic myeloid leukemia [J] . JabbourE., Garcia-ManeroG., CortesJ., Clinical lymphoma, myeloma & leukemia . 2012,第4期

机译：每天两次氟达拉滨和阿糖胞苷联合或不联合使用ozuzamicin或对genuzumab ozogamicin的治疗对复发/难治性急性髓细胞性白血病，高危骨髓增生异常综合症和爆炸性慢性髓细胞性白血病患者有效
3. Numerical chromosomal changes and risk of development of myelodysplastic syndrome--acute myeloid leukemia in patients with Fanconi anemia. [J] . Mehta PA, Harris RE, Davies SM, Cancer genetics and cytogenetics . 2010,第2期

机译：Fanconi贫血患者的染色体数字变化和骨髓增生异常综合症-急性髓性白血病的发展风险。
4. Ras gene mutation in acute myeloid leukemia and Myelodysplastic syndromes: a meta-analysis of its occurrence and prognostic relevance [C] . Cheng Jingru, Wang Peng, Zhang Tai, International Conference on Advanced Materials and Computer Science . 2016

机译：RAS基因突变在急性髓性白血病和髓细胞增强综合征中：荟萃分析其发生和预后相关性
5. Myelodysplastic Syndrome Progression to Acute Myeloid Leukemia at the Stem Cell Level [D] . Chen, Jiahao. 2018

机译：在干细胞水平上骨髓增生异常综合征进展为急性髓细胞性白血病
6. JAK2 V617F mutation in myelodysplastic syndrome myelodysplastic syndrome/myeloproliferative neoplasm unclassifiable refractory anemia with ring sideroblasts with thrombocytosis and acute myeloid leukemia [O] . Dong Wook Jekarl, Sang Bong Han, Myungshin Kim, 2010

机译：骨髓增生异常综合症骨髓增生异常综合症/骨髓增生性肿瘤无法分类的难治性贫血伴环铁粒母细胞伴血小板增多症和急性髓样白血病的JAK2 V617F突变
7. JAK2 V617F mutation in myelodysplastic syndrome, myelodysplastic syndrome/myeloproliferative neoplasm, unclassifiable, refractory anemia with ring sideroblasts with thrombocytosis, and acute myeloid leukemia [O] . Jekarl, Dong Wook, Han, Sang Bong, Kim, Myungshin, 2010

机译：JAK2 V617F突变在骨髓增生异常综合症，骨髓增生异常综合症/骨髓增生性肿瘤，无法分类的难治性贫血伴环铁粒母细胞伴血小板增多症和急性髓细胞性白血病

Association of gastrointestinal stromal tumor and acute myeloid leukemia preceded by myelodysplastic syndrome with refractory anemia.

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