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首页> 外文期刊>Tumori. >Changes in glucose metabolism during and after radiotherapy in non-small cell lung cancer.
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Changes in glucose metabolism during and after radiotherapy in non-small cell lung cancer.

机译：非小细胞肺癌放疗期间和放疗后葡萄糖代谢的变化。

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AIMS AND BACKGROUND: Evaluation of the metabolic response to radiotherapy in nonsmall cell lung cancer patients is commonly performed about three months after the end of radiotherapy. The aim of the present study was to assess with positron emission tomography/computed tomography (PET/CT) and [18F]fluorodeoxyglucose changes in glucose metabolism during and after radiotherapy in non-small cell lung cancer patients. METHODS AND STUDY DESIGN: In 6 patients, PET/CT scans with [18F]fluorodeoxyglucose were performed before (PET0), during (PET1; at a median of 14 days before the end of radiotherapy) and after the end of radiotherapy (PET2 and PET3, at a median of 28 and 93 days, respectively). The metabolic response was scored according to visual and semiquantitative criteria. RESULTS: Standardize maximum uptake at PET1 (7.9 +/- 4.8), PET2 (5.1 +/- 4.1) and PET3 (2.7 +/- 3.1) were all significantly (P < 0.05; ANOVA repeated measures) lower than at PET0 (16.1 +/- 10.1). Standardized maximum uptake at PET1 was significantly higher than at both PET2 and PET3. There were no significant differences in SUV(max) between PET2 and PET3. PET3 identified 4 complete and 2 partial metabolic responses, whereas PET1 identified 6 partial metabolic responses. Radiotherapy-induced increased [l8F]fluorodeoxyglucose uptake could be visually distinguished from tumor uptake based on PET/CT integration and was less frequent at PET1 (n = 2) than at PET3 (n = 6). CONCLUSION: In non-small cell lung cancer, radiotherapy induces a progressive decrease in glucose metabolism that is greater 3 months after the end of treatment but can be detected during the treatment itself. Glucose avid, radiotherapy-induced inflammation is more evident after the end of radiotherapy than during radiotherapy and does not preclude the interpretation of [18F]fluorodeoxyglucose images, particularly when using PET/CT.
机译：目的和背景：通常在放疗结束后三个月左右评估非小细胞肺癌患者对放疗的代谢反应。本研究的目的是评估正电子发射断层扫描/计算机断层扫描（PET / CT）和[18F]氟脱氧葡萄糖在非小细胞肺癌患者放疗期间和放疗后葡萄糖代谢的变化。方法和研究设计：6例患者在（PET0）之前，期间（PET1;放疗结束前中位14天）和放疗结束后（PET2和PET3，分别为28天和93天。根据视觉和半定量标准对代谢反应进行评分。结果：标准化的最大摄取量在PET1（7.9 +/- 4.8），PET2（5.1 +/- 4.1）和PET3（2.7 +/- 3.1）上均显着（P <0.05; ANOVA重复测量）均低于PET0（16.1） +/- 10.1）。 PET1的标准最大摄入量显着高于PET2和PET3。 PET2和PET3之间的SUV（max）没有显着差异。 PET3鉴定出4个完全代谢反应和2个部分代谢反应，而PET1鉴定出6个部分代谢反应。放射疗法诱导的[18 F]氟脱氧葡萄糖摄取的增加可通过PET / CT整合在视觉上与肿瘤摄取区别开来，并且在PET1（n = 2）时比在PET3（n = 6）时少。结论：在非小细胞肺癌中，放疗会导致葡萄糖代谢的逐步下降，这种下降在治疗结束后3个月内更大，但可以在治疗过程中自行检测到。与放疗相比，放疗结束后葡萄糖狂热，放疗引起的炎症更加明显，并且不排除[18F]氟脱氧葡萄糖图像的解释，尤其是在使用PET / CT时。

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