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首页> 外文期刊>Tumori. >Atypical lobular hyperplasia and lobular carcinoma in situ without other high-risk lesions diagnosed on vacuum-assisted core needle biopsy. The problem of excisional biopsy.
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Atypical lobular hyperplasia and lobular carcinoma in situ without other high-risk lesions diagnosed on vacuum-assisted core needle biopsy. The problem of excisional biopsy.

机译：非典型小叶增生和小叶原位癌，无其他高危病变，经真空辅助穿刺活检确诊。切除活检的问题。

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AIMS: Verification of clinical procedure in patients with primary diagnosis of lobular carcinoma in situ and atypical lobular hyperplasia found on the basis of 11-gauge mammotomic biopsy. MATERIAL AND METHODS: A retrospective evaluation of 4326 mammotomic biopsies carried out in one clinic by three oncological surgeons in view of the diagnosed lobular carcinoma in situ or atypical lobular hyperplasia without concomitant invasive lesions. Biopsies showed that lobular carcinoma in situ or atypical lobular hyperplasia were concomitant lesions with benign changes of the mammary gland. RESULTS: Of 16 cases of lobular carcinoma in situ, invasive ductal cancer was observed in 2 patients, invasive lobular cancer in 2 patients, and ductal carcinoma in situ in 1 case. Seven patients did not undergo surgery but were kept under intensive oncological supervision. Of 17 cases of atypical lobular hyperplasia, after surgery it turned out that there were 4 cases of invasive ductal cancer and 1 case of ductal carcinoma in situ. Five patients did not undergo surgery but were kept under intensive oncological supervision. CONCLUSIONS: After initial mammotomic diagnosis of lobular carcinoma in situ, invasive carcinoma or ductal carcinoma in situ was found in 31.25% of the cases and atypical lobular hyperplasia in 29.4%. This suggests that lobular neoplasia on core needle biopsy should prompt surgery. The open question is what factors are associated with the lower probability of concomitant invasive cancer. It seems that for isolated microcalcifications, which are totally removed in core biopsy, we can offer a close follow-up. We will have to wait for a follow-up longer than 2 years to be sure that surveillance is recommended for totally removed isolated microcalcifications.
机译：目的：对11例乳房X线检查活检发现原发性小叶癌和非典型小叶增生的患者的临床程序进行验证。材料和方法：回顾性评估由三名肿瘤外科医师在一个诊所中进行的4326例乳房X线活组织检查，以诊断为原发性小叶癌或不伴有浸润性病变的非典型小叶增生。活检表明，原位小叶癌或非典型小叶增生是伴随乳腺良性变化的病变。结果：16例小叶原位癌中，浸润性导管癌2例，浸润性小叶癌2例，导管原位癌1例。七名患者没有接受手术治疗，但受到了严格的肿瘤学监督。在手术后的17例非典型小叶增生中，有4例浸润性导管癌和1例原位导管癌。五名患者没有接受手术治疗，但仍接受了严格的肿瘤学监督。结论：在最初对小叶原位癌进行乳腺肿瘤诊断后，发现浸润性癌或导管原位癌的比例为31.25％，非典型性小叶增生的比例为29.4％。这表明在活检针上进行小叶增生应该提示手术。悬而未决的问题是哪些因素与并发浸润性癌症的可能性降低相关。对于核心活检中完全去除的孤立微钙化，我们可以提供密切随访。我们必须等待超过2年的随访，以确保建议对完全去除的孤立微钙化进行监测。

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