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首页> 外文期刊>Tumori. >Concurrent versus sequential administration of CMF chemotherapy and radiotherapy after breast-conserving surgery in early breast cancer.
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Concurrent versus sequential administration of CMF chemotherapy and radiotherapy after breast-conserving surgery in early breast cancer.

机译：早期乳腺癌保乳手术后同时进行和顺序进行CMF化疗和放疗。

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AIMS AND BACKGROUND: To compare the outcome of concurrent versus sequential administration of cyclophosphamide, methotrexate, and 5-fluorouracil (CMF) chemotherapy and radiotherapy after breast-conserving surgery in early breast cancer. METHODS: From February 1992 to January 2002, 156 patients underwent CMF chemotherapy and radiotherapy, either concurrently (CCRT group, 88 patients) or sequentially (SCRT group, 68 patients). There was a predilection of patients with a larger tumor (P = 0.0035), with more frequent nodal involvement (P = 0.0686), and younger age (P = 0.0776) in the CCRT group. RESULTS: The planned radiotherapy was completed in every patient. No grade 3 or 4 late treatment-related toxicity was observed in the CCRT or SCRT group. Compliance to the treatment as well as cosmetic outcome of the two groups were comparable. Despite more adverse factors for local-regional recurrence in the CCRT group, the 5-year local-regional control rate of the CCRT group was similar to that of the SCRT group (97.7% vs 93.8%, respectively, P = 0.1688). On multivariate analysis, concomitant administration of chemotherapy and radiotherapy was associated with improved local-regional control (P = 0.0463). CONCLUSIONS: Concurrent administration of CMF chemotherapy and radiotherapy resulted in improved local-regional control over sequential administration without an increase in significant toxicity. Concurrent CMF chemoradiotherapy may serve as a viable option for patients at high-risk of local-regional relapse not suitable for anthracycline or taxane-based chemotherapy.
机译：目的和背景：比较早期乳腺癌保乳手术后同时施用环磷酰胺，甲氨蝶呤和5-氟尿嘧啶（CMF）化疗和放疗的结果。方法：从1992年2月至2002年1月，有156例患者接受了CMF化疗和放疗，同时（CCRT组88例）或序贯（SCRT组68例）进行。 CCRT组有较大肿瘤（P = 0.0035），淋巴结受累（P = 0.0686）和年龄较小（P = 0.0776）的患者。结果：每位患者均完成了计划的放疗。在CCRT或SCRT组中未观察到3级或4级晚期治疗相关毒性。两组的治疗依从性和美容效果相当。尽管CCRT组的局部区域复发有更多不利因素，但CCRT组的5年局部区域控制率与SCRT组相似（分别为97.7％和93.8％，P = 0.1688）。在多变量分析中，化学疗法和放疗的同时给药与局部控制的改善相关（P = 0.0463）。结论：CMF化学疗法和放射疗法的同时给药导致顺序给药的局部区域控制得到改善，而没有明显的毒性增加。对于不适合使用蒽环类或紫杉烷类化学疗法的局部复发高危患者，并发CMF放化疗可能是一种可行的选择。

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