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首页> 外文期刊>Tumori. >Carboplatin plus taxol is an effective third-line regimen in recurrent undifferentiated nasopharyngeal carcinoma.
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Carboplatin plus taxol is an effective third-line regimen in recurrent undifferentiated nasopharyngeal carcinoma.

机译：卡铂加紫杉醇是复发性未分化鼻咽癌的有效三线方案。

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BACKGROUND: Recurrent undifferentiated nasopharyngeal carcinoma is a chemosensitive disease. Few third-line treatments have been reported. METHODS: Twelve patients (9 males, 3 females; median age 50 years, range, 20-62) with recurrent undifferentiated nasopharyngeal carcinoma were treated with carboplatin AUC 5.5 + paclitaxel (175 mg/m2, 3-hr infusion) on day 1 every 3 weeks. All patients had been previously treated for recurrent disease with a first-line cisplatin-based chemotherapy and a second-line therapy with low-dose continuous infusion 5-fluorouracil. RESULTS: Overall, 54 courses were given (median, 5; range, 2-6). Three patients (25%) obtained a partial response lasting 6, 10 and 26+ months, 1 (8.3%) a minimal response lasting 6 months, and 3 (25%) no change with a median duration of 5 months. The median survival time was 14 months for patients who had a partial or minimal response or no change, and 5 months for nonresponders. Median overall survival was 9.5 months (3-30+). The treatment was well tolerated, and toxicity was manageable. CONCLUSIONS: The combination has a good palliative role as third-line chemotherapy in recurrent undifferentiated nasopharyngeal cancer.
机译：背景：复发性未分化鼻咽癌是一种化学敏感性疾病。很少有三线治疗的报道。方法：每隔第1天，对12例复发性未分化鼻咽癌患者（男9例，女3例;中位年龄50岁，范围20-62岁）进行卡铂AUC 5.5 +紫杉醇（175 mg / m2，3小时输注）治疗3周。所有患者先前均已接受基于一线顺铂的化学疗法和二线治疗与小剂量连续输注5-氟尿嘧啶的复发性疾病治疗。结果：总共提供了54门课程（中位数为5;范围为2-6）。 3例患者（25％）获得了持续6、10和26个月以上的部分缓解，1例（8.3％）持续了6个月的轻微缓解，3例（25％）的中位持续时间为5个月。有部分或最小反应或无变化的患者的中位生存时间为14个月，无反应者为5个月。中位总生存期为9.5个月（3-30岁以上）。治疗耐受性好，毒性可控。结论：该组合作为复发性未分化鼻咽癌的三线化疗具有良好的姑息作用。

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