• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Tumour biology : >Clinical significance of Maspin promoter methylation and loss of its protein expression in invasive ductal breast carcinoma: correlation with VEGF-A and MTA1 expression.
【24h】

Clinical significance of Maspin promoter methylation and loss of its protein expression in invasive ductal breast carcinoma: correlation with VEGF-A and MTA1 expression.

机译：Maspin启动子甲基化及其在浸润性导管癌中蛋白表达缺失的临床意义：与VEGF-A和MTA1表达的相关性。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Maspin is a serine protease inhibitor with tumor-suppressor activity. Maspin can suppress tumor growth and metastasis in vivo and tumor cell motility and invasion in vitro. Previous studies indicate that the loss of Maspin expression is closely linked to aberrant methylation of the Maspin promoter. We examined the promoter methylation status of Maspin in tumor and corresponding serum of breast cancer patients. In addition, protein expression of this gene was also assessed to determine possible correlation between promoter hypermethylation and gene silencing. Further, we investigated the correlation of Maspin expression with vascular endothelial growth factor (VEGF-A) and MTA1 expression. Maspin methylation was analyzed by methylation-specific PCR in 100 invasive ductal breast carcinoma patients' tumors and circulating DNA in a prospective study. Promoter hypermethylation was correlated with expression of the encoded protein in tumors by immunohistochemistry. Significant correlation was observed between promoter hypermethylation of Maspin (r = +0.88; p
机译：Maspin是一种具有肿瘤抑制活性的丝氨酸蛋白酶抑制剂。 Maspin可以抑制体内肿瘤的生长和转移以及体外肿瘤细胞的运动和侵袭。先前的研究表明，Maspin表达的丧失与Maspin启动子的异常甲基化密切相关。我们检查了Maspin在乳腺癌患者的肿瘤和相应血清中的启动子甲基化状态。另外，还评估了该基因的蛋白质表达，以确定启动子高甲基化与基因沉默之间的可能相关性。此外，我们调查了Maspin表达与血管内皮生长因子（VEGF-A）和MTA1表达的相关性。在一项前瞻性研究中，通过甲基化特异性PCR对100例浸润性导管癌患者的肿瘤和循环DNA进行了Maspin甲基化分析。通过免疫组织化学，启动子高甲基化与肿瘤中编码蛋白的表达相关。观察到肿瘤中Maspin的启动子高甲基化（r = +0.88; p

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号