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首页> 外文期刊>Tumour biology : >Expression of the Breast Cancer Metastasis Suppressor Gene, BRMS1, in Human Breast Carcinoma: Lack of Correlation with Metastasis to Axillary Lymph Nodes.
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Expression of the Breast Cancer Metastasis Suppressor Gene, BRMS1, in Human Breast Carcinoma: Lack of Correlation with Metastasis to Axillary Lymph Nodes.

机译：乳腺癌转移抑制基因BRMS1在人乳腺癌中的表达：与腋窝淋巴结转移的相关性缺乏。

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摘要

The BRMS1 (breast cancer metastasis suppressor 1) gene has been found to suppress metastasis in animal models without inhibiting primary tumor growth. The aim of this study was to measure expression of BRMS1 mRNA in a panel of human breast carcinomas and compare its expression with parameters of local dissemination such as tumor size and lymph node metastasis. We also compared expression of BRMS1 mRNA in normal breast tissue, fibroadenomas, primary breast cancers and axillary nodal metastases from primary breast cancers. BRMS1 mRNA was detected in 10/11 (90%) specimens of normal breast tissue, 12/16 (75%) fibroadenomas, 64/82 (78%) primary breast cancer and 11/15 (64%) lymph node metastases (p, NS). In the primary cancer, expression was independent of tumor size, tumor grade, metastasis to axillary nodes and hormone receptor status. Furthermore, similar levels of BRMS1 were found in normal breast tissue, primary breast carcinomas and lymph node metastases from primary breast cancer. Our results do not suggest a role for BRMS1 in suppressing metastasis to local lymph nodes in patients with breast cancer. Copyright (c) 2005 S. Karger AG, Basel.
机译：已发现BRMS1（乳腺癌转移抑制因子1）基因可在动物模型中抑制转移而不会抑制原发性肿瘤的生长。这项研究的目的是测量一组人类乳腺癌中BRMS1 mRNA的表达并将其表达与局部扩散参数（例如肿瘤大小和淋巴结转移）进行比较。我们还比较了正常乳腺组织，纤维腺瘤，原发性乳腺癌和原发性乳腺癌的腋窝淋巴结转移中BRMS1 mRNA的表达。在10/11（90％）正常乳腺组织，12/16（75％）纤维腺瘤，64/82（78％）原发性乳腺癌和11/15（64％）淋巴结转移标本中检测到BRMS1 mRNA（p ，NS）。在原发癌中，表达与肿瘤大小，肿瘤等级，转移至腋窝淋巴结和激素受体状态无关。此外，在正常乳腺组织，原发性乳腺癌和原发性乳腺癌的淋巴结转移中发现了相似水平的BRMS1。我们的结果并不表明BRMS1在抑制乳腺癌患者局部淋巴结转移中的作用。版权所有（c）2005 S.Karger AG，巴塞尔。

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