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The clinical value of dynamic contrast-enhanced MRI in differential diagnosis of malignant and benign ovarian lesions

机译：动态对比增强MRI在卵巢良恶性病变鉴别诊断中的临床价值

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Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is widely used in preoperative diagnosis of various tumors. We investigated the clinical value of DCE-MRI in differential diagnosis of malignant and benign ovarian lesions. The study involved 48 subjects with surgical pathology-confirmed ovarian tumors with solid components. Early dynamic phase enhancement performances of the ovarian lesions in patients were assessed, including the enhancement pattern, time-signal intensity curve (TIC), signal intensity rate at the initial 60 s (SI60), time to peak within 200 s (TTP200), and slope ratio. There were significant differences in enhancement patterns between benign and malignant ovarian tumors (P<0.05). A total of 30 malignant tumors (30/31) displayed type I TIC, 8 benign tumors (8/13) showed type III TIC, and significant differences were found in TIC type between malignant and benign ovarian lesions (P<0.01). Benign ovarian tumors showed lower SI60 (%) and slope ratio, as well as significantly prolonged TTP20, compared to malignant ovarian tumors (all P<0.01). The microvessel count (MVC) of malignant tumors was significantly higher than that of benign tumors (P<0.05). Receiver operating characteristic (ROC) curve analyses revealed that DCE-MRI provided an optimal diagnostic performance with threshold values of SI60 at 83.40 %, TTP200 at 77.65 s, and slope ratio at 4.12. These findings revealed that DCE-MRI provides critical information required for differential diagnosis of malignant and benign ovarian lesions.
机译：动态对比增强磁共振成像（DCE-MRI）被广泛用于各种肿瘤的术前诊断。我们调查了DCE-MRI在鉴别恶性和良性卵巢病变中的临床价值。这项研究涉及48位经手术病理证实为具有固体成分的卵巢肿瘤的受试者。评估了患者卵巢病变的早期动态阶段增强性能，包括增强模式，时间信号强度曲线（TIC），初始60 s（SI60）的信号强度速率，200 s内达到峰值的时间（TTP200），和斜率。卵巢良性和恶性肿瘤的增强方式有显着差异（P <0.05）。共有30例恶性肿瘤（30/31）表现为I型TIC，8例良性肿瘤（8/13）表现为III型TIC，在恶性和卵巢良性病变之间TIC类型存在显着差异（P <0.01）。与恶性卵巢肿瘤相比，良性卵巢肿瘤显示出较低的SI60（％）和斜率，以及显着延长的TTP20（所有P <0.01）。恶性肿瘤的微血管计数（MVC）明显高于良性肿瘤（P <0.05）。接收器工作特征（ROC）曲线分析显示DCE-MRI提供了最佳的诊断性能，其SI60的阈值为83.40％，TTP200的阈值为77.65 s，斜率为4.12。这些发现表明DCE-MRI提供了鉴别诊断恶性和良性卵巢病变所需的关键信息。

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