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首页> 外文期刊>Tumour biology : >Combination of platelet count and mean platelet volume (COP-MPV) predicts postoperative prognosis in both resectable early and advanced stage esophageal squamous cell cancer patients
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Combination of platelet count and mean platelet volume (COP-MPV) predicts postoperative prognosis in both resectable early and advanced stage esophageal squamous cell cancer patients

机译：血小板计数和平均血小板体积（COP-MPV）的结合可预测可切除的早期和晚期食管鳞癌患者的术后预后

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The aim of this study is to search the most powerful prognostic factor from routine blood test for esophageal squamous cell cancer (ESCC) patients. Multiple laboratory tests were evaluated including those reflecting red blood cell parameters (hemoglobin (Hb), mean corpuscular volume (MCV), mean corpuscular hemoglobin concentration (MCHC), and red blood cell distribution width (RDW)), platelet morphological parameters (mean platelet volume (MPV) and platelet count (PLT)), blood coagulation status (D-dimer), and tumor biomarker (CA19-9). Known inflammatory indices (NLR and PLR) were also calculated. A total of 468 patients who were diagnosed with ESCC between December 2005 and December 2008 were retrospectively analyzed in this study. By utilizing univariate and multivariate Cox proportional hazard analyses, we found that PLT and MPV were significantly associated with overall survival (OS) and disease-free survival (DFS) of ESCC patients, with optimal cutoff values of 212 and 10.6, respectively. Moreover, the combination of the preoperative PLT and MPV (COP-MPV) was calculated as follows: patients with both PLT (aeyen212 x 10(9) L-1) and MPV (aeyen10.6 fL) elevation were assigned a score of 2, and patients with one or neither were assigned a score of 1 and 0. The COP-MPV was an independent prognostic factor for OS (hazard ratio (HR) 0.378, 95 % confidence interval (CI) 0.241 to 0.593, P < 0.001, 0/2) and DFS (HR 0.341, 95 % CI 0.218 to 0.534, P < 0.001, 0/2) in multivariate analyses. In subgroup analyses for early (stages I and II) and locally (stage III) advanced stage patients, COP-MPV was found significantly associated with OS and DFS in each group (P = 0.025 and P = 0.018 for OS and P = 0.029 and P = 0.002 for DFS). In conclusion, we considered that COP-MPV is a promising predictor for postoperative survival in ESCC patients.
机译：这项研究的目的是从常规血液检查中寻找食管鳞状细胞癌（ESCC）患者最有力的预后因素。评估了多个实验室测试，包括反映红细胞参数（血红蛋白（Hb），平均红细胞体积（MCV），平均红细胞血红蛋白浓度（MCHC）和红细胞分布宽度（RDW）），血小板形态学参数（平均血小板）的测试。 （MPV）和血小板计数（PLT）），凝血状态（D-二聚体）和肿瘤生物标志物（CA19-9）。还计算了已知的炎症指数（NLR和PLR）。这项研究回顾性分析了2005年12月至2008年12月之间共468名被诊断为ESCC的患者。通过使用单变量和多变量Cox比例风险分析，我们发现PLT和MPV与ESCC患者的总生存期（OS）和无病生存期（DFS）显着相关，最佳临界值分别为212和10.6。此外，术前PLT和MPV（COP-MPV）的组合计算如下：PLT（aeyen212 x 10（9）L-1）和MPV（aeyen10.6 fL）升高的患者的得分均为2 ，而只有一个或没有一个的患者的得分分别为1和0。COP-MPV是OS的独立预后因素（危险比（HR）0.378，95％置信区间（CI）0.241至0.593，P <0.001， 0/2）和DFS（HR 0.341，95％CI 0.218至0.534，P <0.001，0/2）进行多变量分析。在早期（I和II期）和局部（III期）晚期患者的亚组分析中，发现COP-MPV与每组OS和DFS显着相关（OS分别为P = 0.025和P = 0.018，P = 0.029和对于DFS，P = 0.002）。总之，我们认为COP-MPV是ESCC患者术后生存的有希望的预测指标。

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