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首页> 外文期刊>Trends in immunology >A central role for peripheral dendritic cells in the induction of acquired thymic tolerance.
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A central role for peripheral dendritic cells in the induction of acquired thymic tolerance.

机译：外周树突状细胞在诱导获得性胸腺耐受中的核心作用。

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摘要

Despite extensive negative selection in the thymus, numerous clones of self-reactive T cells are normally exported to the periphery. In most instances, autoimmunity is prevented by regulatory T (Tr) cells, many of which are also of recent thymic origin. We have demonstrated recently that natural killer (NK) Tr thymocytes (THYr) can be induced by the injection of antigen into the eye, an immunologically privileged site; and that the intravenous infusion of antigen-presenting cells (APCs) from such animals also induces NKT THYr. Furthermore, we have also observed that some of these APCs migrate to the thymus as CD11c(+) dendritic cells (DCs). Other authors have correlated the migration of DCs to the thymus with the generation of CD4(+)CD25(+) THYr. We therefore propose a novel tolerance induction pathway by which tolerogenic DCs routinely transport antigen (both self and nonself) from the periphery to the thymus, where they positively select THYr. We also propose that the ability of tolerogenic DCs to induce acquired thymic tolerance on demand might have important implications for the immunotherapy of autoimmunity and allotransplantation.
机译：尽管在胸腺中有广泛的阴性选择，但自反应性T细胞的许多克隆通常会输出到外周。在大多数情况下，调节性T（Tr）细胞可预防自身免疫，其中许多也是最近胸腺起源的。最近我们证明，通过将抗原注射到眼睛（一种免疫学上优先的位点）可以诱导自然杀伤（NK）Tr胸腺细胞（THYr）。并且从这些动物中静脉滴注抗原呈递细胞（APC）也会诱导NKT THYr。此外，我们还观察到其中一些APC作为CD11c（+）树突状细胞（DC）迁移到胸腺。其他作者将DC迁移到胸腺与CD4（+）CD25（+）THYr的产生相关。因此，我们提出了一种新颖的耐受诱导途径，通过该途径，致耐受性DC常规地将抗原（自身和非自身的）从外周转运至胸腺，在那里它们会积极选择THYr。我们还提出，耐受性DC按需诱导获得的胸腺耐受的能力可能对自身免疫和同种异体移植的免疫治疗具有重要意义。

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