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首页> 外文期刊>Trends in immunology >Cancer immunoprevention: tracking down persistent tumor antigens.
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Cancer immunoprevention: tracking down persistent tumor antigens.

机译:癌症免疫预防:追踪持久性肿瘤抗原。

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摘要

The immune response can effectively hamper the progression of preclinical stages of tumor growth. Medicine in the postgenomic era offers an increasing possibility of detecting healthy individuals at risk of developing cancer who could benefit from tumor-preventive vaccines. The identification of novel tumor antigens that fulfill two conditions will be crucial for the development of cancer immunoprevention. First, an ideal antigen should have a crucial pathogenetic role in tumor growth to avoid the selection of antigen-loss variants. Second, the antigen should be recognizable by the immune system even in MHC-loss variants and should therefore be recognized both by antibodies and T cells. Identifying such antigens will also provide new targets for cancer immunotherapy.
机译:免疫反应可以有效地阻止肿瘤生长的临床前阶段的发展。后基因组时代的医学提供了越来越多的可能性,可以发现可能受益于肿瘤预防疫苗的罹患癌症风险的健康个体。满足两个条件的新型肿瘤抗原的鉴定对于癌症免疫预防的发展至关重要。首先,理想的抗原应在肿瘤生长中具有关键的致病作用,以避免选择抗原丢失的变异体。其次,即使在MHC丢失的变体中,抗原也应能被免疫系统识别,因此应同时被抗体和T细胞识别。鉴定此类抗原还将为癌症免疫疗法提供新的靶标。

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