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首页> 外文期刊>Trends in immunology >Regulation of quiescence in lymphocytes.
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Regulation of quiescence in lymphocytes.

机译:淋巴细胞的静止调节。

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摘要

Cellular quiescence is a state characterized by decreased cell size and metabolic activity. In quiescent nai;ve lymphocytes, antigen recognition with appropriate co-stimulation triggers exit from G0 phase of the cell cycle, increased size and metabolism and progression through the cell cycle. Recent studies have shown that quiescence in lymphocytes is an actively maintained state rather than a default pathway in the absence of signal. Certain transcription factors appear to act as master regulators of gene expression patterns that enforce the quiescent phenotype. Here, we discuss candidate lymphocyte quiescence factors and their potential target genes and mechanisms of action.
机译:细胞静止是以细胞大小和代谢活性降低为特征的状态。在静止的天然淋巴细胞中,具有适当共刺激作用的抗原识别触发了细胞周期G0期的退出,增加了细胞大小,代谢和整个细胞周期的进程。最近的研究表明,在没有信号的情况下,淋巴细胞的静止是一种主动维持的状态,而不是默认途径。某些转录因子似乎充当了强制静止表型的基因表达模式的主要调控因子。在这里,我们讨论候选淋巴细胞静止因子及其潜在的靶基因和作用机制。

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