Lymphocytes transport serotonin and dopamine: agony or ecstasy?

Gordon J; Barnes NM

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Lymphocytes transport serotonin and dopamine: agony or ecstasy?

机译：淋巴细胞转运5-羟色胺和多巴胺：是痛苦还是摇头丸？

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Lymphocytes apparently carry active transport systems for the neurotransmitters serotonin and dopamine. Meanwhile, pharmacological substrates for the transporters have been claimed to impinge on immune function: these include, commonly used antidepressants [such as fluoxetine (Prozac((R)))], appetite suppressants and the recreational drugs MDMA [3,4-Methylenedioxymethamphetamine ('Ecstasy')] and cocaine. Data on these issues can be patchy. Given the widespread use - or, abuse - of these drugs, we propose that a concerted effort should be made towards a full description of biogenic amine transporters in the immune system and the potential impact of their substrates - both natural and artificial - on its functioning. Could such knowledge one day help to treat immune deficiency and/or dysregulation?

机译：淋巴细胞显然带有神经递质5-羟色胺和多巴胺的主动转运系统。同时，据报道转运蛋白的药理底物会影响免疫功能：包括常用的抗抑郁药[例如氟西汀（Prozac（R））]，食欲抑制剂和休闲药MDMA [3,4-Methyldioxymethamphetamine（ “摇头丸”）和可卡因。关于这些问题的数据可能不完整。鉴于这些药物的广泛使用（或滥用），我们建议做出一致努力，全面描述免疫系统中生物胺转运蛋白及其天然和人工底物的潜在作用对其功能的潜在影响。。有一天这种知识可以帮助治疗免疫缺陷和/或机能失调吗？

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《Trends in immunology》 |2003年第8期|共6页
作者
Gordon J; Barnes NM;
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正文语种 eng
中图分类医学免疫学;
关键词
Ecstasy - drug; Serotonin; Lymphocytes; Dopamine; description; 血清素; 淋巴细胞; 多巴胺;

机译：Ecstasy - drug;Serotonin;Lymphocytes;Dopamine;description;血清素;淋巴细胞;多巴胺;

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1. Lymphocytes transport serotonin and dopamine: agony or ecstasy? [J] . Gordon J, Barnes NM Trends in immunology . 2003,第8期

机译：淋巴细胞转运5-羟色胺和多巴胺：是痛苦还是摇头丸？
2. Positron emission tomographic studies of brain dopamine and serotonin transporters in abstinent (±)3,4-methylenedioxymethamphetamine (“ecstasy”) users: relationship to cognitive performance [J] . Una D. McCann, Zsolt Szabo, Melin Vranesic, Psychopharmacology . 2008,第3期

机译：正（+）3,4-亚甲二氧基甲基苯丙胺（“摇头丸”）用户脑中多巴胺和5-羟色胺转运体的正电子发射断层扫描研究：与认知表现的关系
3. MDMA (Ecstasy) and human dopamine, norepinephrine, and serotonin transporters: implications for MDMA-induced neurotoxicity and treatment. [J] . Verrico CD, Miller GM, Madras BK Psychopharmacology . 2007,第4期

机译：MDMA（摇头丸）和人多巴胺，去甲肾上腺素和5-羟色胺转运蛋白：对MDMA诱导的神经毒性和治疗的影响。
4. Reproducibility of Dopamine and Serotonin Transporter Binding Measured with Single-Photon Emission Computed Tomography [C] . A. Uusitalo, M.A. Hakulinen, J.T. Kuikka World congress on medical physics and biomedical engineering;International congress of the IUPESM . 2011

机译：用单光子发射计算机断层扫描测量多巴胺和5-羟色胺转运蛋白结合的重现性。
5. Sibling-based association study of dopamine transporter, serotonin transporter, and dopamine-4 receptor polymorphisms and disordered eating behavior in young adults. [D] . Sobik, Laura Elizabeth. 2007

机译：基于兄弟姐妹的多巴胺转运蛋白，血清素转运蛋白和多巴胺-4受体多态性与年轻人饮食行为紊乱的关联研究。
6. Positron Emission Tomographic Studies of Brain Dopamine and Serotonin Transporters in Abstinent (±) 34-Methylenedioxymethamphetamine (Ecstasy) Users: Relationship to Cognitive Performance [O] . Una D. McCann, Zsolt Szabo, Melin Vranesic, -1

机译：正（±）34-亚甲二氧基甲基苯丙胺（摇头丸）使用者脑中多巴胺和5-羟色胺转运蛋白的正电子发射断层扫描研究：与认知表现的关系
7. MDMA (Ecstasy) and human dopamine, norepinephrine, and serotonin transporters: implications for MDMA-induced neurotoxicity and treatment [O] . Christopher D. Verrico, Gregory M. Miller, Bertha K. Madras 2005

机译：MDMA（exstasy）和人类多巴胺，去甲肾上腺素和血清素转运蛋白：对MDMA诱导的神经毒性和治疗的影响

Lymphocytes transport serotonin and dopamine: agony or ecstasy?

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