Re-examining the Nature and Function of Self-Reactive T cells

Richards David M.; Kyewski Bruno; Feuerer Markus

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Re-examining the Nature and Function of Self-Reactive T cells

机译：重新检查自身反应性T细胞的性质和功能

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Recent studies have leveraged MHC tetramer and TCR sequencing approaches towards a more precise characterization of the peripheral T cell repertoire, providing important insight into both the contribution of self-reactive T cells to the overall repertoire and their function. The peripheral T cell repertoire of healthy individuals contains a high frequency of diverse, self-reactive T cells. Furthermore, self-reactive T cells can perform essential beneficial physiological functions. We review these recent findings here, and discuss their implications to the current understanding of peripheral tolerance and the role of self-reactive T cells in autoimmune disease. We outline gaps in understanding, and argue that an important step forward is to revise the definition of self-reactive T cells to incorporate new concepts regarding the nature and physiological functions of different populations of T cells capable of recognizing self-antigens.

机译：最近的研究已经利用MHC四聚体和TCR测序方法对外周T细胞库进行更精确的表征，从而为自反应性T细胞对整个库的贡献及其功能提供了重要的见识。健康个体的外周T细胞库包含多种多样的自我反应性T细胞。此外，自我反应性T细胞可以执行基本有益的生理功能。我们在这里回顾了这些最新发现，并讨论了它们对周围耐受的当前理解以及自身免疫性T细胞在自身免疫性疾病中的作用。我们概述了理解上的差距，并认为向前迈出的重要一步是修改自我反应性T细胞的定义，以纳入有关能够识别自身抗原的T细胞不同种群的性质和生理功能的新概念。

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《Trends in immunology》 |2016年第2期|共12页
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Richards David M.; Kyewski Bruno; Feuerer Markus;
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正文语种 eng
中图分类医学免疫学;
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1. Re-examining the Nature and Function of Self-Reactive T cells [J] . Richards David M., Kyewski Bruno, Feuerer Markus Trends in immunology . 2016,第2期

机译：重新检查自身反应性T细胞的性质和功能
2. Allogeneic Adipose-Derived Mesenchymal Stromal Cells Ameliorate Experimental Autoimmune Encephalomyelitis by Regulating Self-Reactive T Cell Responses and Dendritic Cell Function [J] . Per Anderson, Elena Gonzalez-Rey, Francisco OValle, Stem cells international . 2017,第1期

机译：同种异体脂肪衍生的间充质基质细胞通过调节自活性T细胞应答和树突细胞功能来改善实验性自身免疫性脑炎
3. Self-reactive T cell hybridomas and tolerance. Same range of antigen dose dependence but higher numbers of self-reactive T cell hybridomas from mice in which self-tolerance has been broken by antiserum treatment. [J] . S C Schneider, N A Mitchison The journal of immunology . 1995,第8期

机译：自身反应性T细胞杂交瘤和耐受性。抗原剂量依赖性的范围相同，但来自小鼠的自身反应性T细胞杂交瘤数量更多，其中通过抗血清治疗破坏了自身耐受性。
4. Cellulose Nanofibrils: Adapting Nature's Building Block for Advanced Structure and Functionality(PPT) [C] . F. Jiang Annual Meeting of the Pulp and Paper Technical Association of Canada . 2019

机译：纤维素纳米纤维：适应大自然的构建模块，以实现高级结构和功能（PPT）
5. Regulation of Self-Reactive B cells: Implications for Complement and Toll-like Receptors [D] . Agyemang, Amma 2011

机译：自我反应性B细胞的调节：对补体和Toll样受体的影响。
6. Anergic self-reactive B cells present self antigen and respond normally to CD40-dependent T-cell signals but are defective in antigen-receptor-mediated functions. [O] . J M Eris, A Basten, R Brink, 1994

机译：无反应的自我反应性B细胞呈递自身抗原并正常响应CD40依赖性T细胞信号但在抗原受体介导的功能上存在缺陷。
7. Anergic self-reactive B cells present self antigen and respond normally to CD40-dependent T-cell signals but are defective in antigen-receptor-mediated functions. [O] . Eris, J M, Basten, A, Brink, R, 1994

机译：无反应的自我反应性B细胞呈递自身抗原，并正常响应CD40依赖性T细胞信号，但在抗原受体介导的功能上存在缺陷。

Re-examining the Nature and Function of Self-Reactive T cells

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