TCR-induced NF-kappaB activation: a crucial role for Carma1, Bcl10 and MALT1.

Thome M; Tschopp J

首页> 外文期刊>Trends in immunology >TCR-induced NF-kappaB activation: a crucial role for Carma1, Bcl10 and MALT1.

【24h】

TCR-induced NF-kappaB activation: a crucial role for Carma1, Bcl10 and MALT1.

机译：TCR诱导的NF-κB激活：对Carma1，Bcl10和MALT1至关重要。

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

T-cell receptor (TCR) engagement induces the maturation of thymocytes and the activation and proliferation of peripheral T cells through signaling pathways that target several transcription factors. The transcription factor nuclear factor-kappaB (NF-kappaB) has an essential role in the activation of mature T cells but the signaling pathway leading from TCR stimulation to NF-kappaB activation is not well defined. Carma1, Bcl10 and MALT1 are recently identified proteins that have an important and previously unexpected role in antigen receptor-induced NF-kappaB activation and the control of lymphocyte proliferation. We believe that the recent advances in this field could stimulate research for the development of new immunomodulatory drugs and could lead to a better understanding of the molecular mechanisms underlying the formation of lymphomas and potentially of other immune disorders.

机译：T细胞受体（TCR）的参与通过靶向几种转录因子的信号传导途径诱导胸腺细胞的成熟以及外周T细胞的活化和增殖。转录因子核因子-kappaB（NF-kappaB）在成熟T细胞的激活中起着至关重要的作用，但是从TCR刺激到NF-kappaB激活的信号通路尚不明确。 Carma1，Bcl10和MALT1是最近鉴定出的蛋白，它们在抗原受体诱导的NF-κB活化和淋巴细胞增殖的控制中具有重要且以前未曾预料到的作用。我们认为，该领域的最新进展可能会刺激对新的免疫调节药物开发的研究，并可能导致人们更好地了解淋巴瘤形成以及潜在的其他免疫疾病的分子机制。

著录项

来源
《Trends in immunology》 |2003年第8期|共6页
作者
Thome M; Tschopp J;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类医学免疫学;
关键词
Not free of; Role; Receptors; Antigen; T-Cell; T-Lymphocytes; 角色; 受体; 抗原; T细胞; T淋巴细胞;

机译：Not free of;Role;Receptors;Antigen;T-Cell;T-Lymphocytes;角色;受体;抗原;T细胞;T淋巴细胞;

相似文献

外文文献
中文文献
专利

1. CXCL12/SDF-1α Activates NF-κB and Promotes Oral Cancer Invasion through the Carma3/Bc110/Malt1 Complex [J] . Aasia O.Rehman, Cun-yu Wang 国际口腔科学杂志（英文版） . 2009,第003期
2. TCR-induced NF-kappaB activation: a crucial role for Carma1, Bcl10 and MALT1. [J] . Thome M, Tschopp J Trends in immunology . 2003,第8期

机译：TCR诱导的NF-κB激活：对Carma1，Bcl10和MALT1至关重要。
3. CARMA1 is a critical lipid raft#150;associated regulator of TCR-induced NF-kappaB activation. [J] . Gaide O, Favier B, Legler DF, Nature immunology . 2002,第9期

机译：CARMA1是重要的脂质筏＃150; TCR诱导的NF-κB活化的相关调节剂。
4. Multiple ITAM-coupled NK-cell receptors engage the Bcl10/Malt1 complex via Carma1 for NF-kappaB and MAPK activation to selectively control cytokine production. [J] . Gross O, Grupp C, Steinberg C, Blood: The Journal of the American Society of Hematology . 2008,第6期

机译：多个ITAM耦合的NK细胞受体通过Carma1参与Bcl10 / Malt1复合物的NF-κB和MAPK激活，以选择性地控制细胞因子的产生。
5. The Signal Pathways Of Immune Inflammation Mediated By The Tlr3/Nf-Kappab And Activator Protein-1 In Cells Infected With Influenza A Virus Antagonized By Baicalin [C] . Chunjing Zhang, Haitao Yu International Conference on Smart Materials and Nanotechnology in Engineering . 2012

机译：在感染甲虫拮抗的细胞中介导的TLR3 / NF-κB和活化剂蛋白-1介导的免疫炎症的信号途径
6. Interaction of PKCbeta with CARMA1 mediates B cell receptor-induced NF-kappaB activation. [D] . Guo, Beichu. 2003

机译：PKCbeta与CARMA1的相互作用介导B细胞受体诱导的NF-κB活化。
7. IκB kinase β–induced phosphorylation of CARMA1 contributes to CARMA1–Bcl10–MALT1 complex formation in B cells [O] . Hisaaki Shinohara, Shiori Maeda, Hiroshi Watarai, 2007

机译：IκB激酶β诱导的CARMA1磷酸化有助于B细胞中CARMA1–Bcl10–MALT1复合物的形成
8. Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-κB activation11The GenBank accession numbers for the human Carma1, Carma2 and Carma3 are AF100338, AF100339 and AF100340, respectively. [O] . Gaide Olivier, Martinon Fabio, Micheau Olivier, 2001

机译：Carma1，Bcl10的含CARD结合伴侣会诱导Bcl10磷酸化和NF-κB活化11。人类Carma1，Carma2和Carma3的GenBank登录号分别为AF100338，AF100339和AF100340。

TCR-induced NF-kappaB activation: a crucial role for Carma1, Bcl10 and MALT1.

摘要

著录项

相似文献

相关主题

期刊订阅