Dectin-1 escape by fungal dimorphism.

Heinsbroek SE; Brown GD; Gordon S

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Dectin-1 escape by fungal dimorphism.

机译：Dectin-1通过真菌二态性逃逸。

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Candida albicans, a medically important fungus, exists primarily as yeast and filamentous forms. Its cell wall is rich in beta-glucans, which are recognized by a lectin-like innate immune receptor, Dectin-1. A recent study shows that exposure of glucan, by yeasts but not filaments, determines Dectin-1-dependent uptake by macrophages, and thus represents a novel immune evasion mechanism. Here, we discuss the insights these results provide in relation to macrophage interactions with C. albicans and pathogen entry.

机译：白色念珠菌是一种重要的真菌，主要以酵母和丝状形式存在。它的细胞壁富含β-葡聚糖，可被凝集素样先天免疫受体Dectin-1识别。最近的一项研究表明，酵母而不是细丝对葡聚糖的暴露决定了巨噬细胞对Dectin-1的依赖，因此代表了一种新型的免疫逃逸机制。在这里，我们讨论这些结果提供的洞察力与巨噬细胞与白色念珠菌相互作用和病原体进入有关。

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《Trends in immunology》 |2005年第7期|共3页
作者
Heinsbroek SE; Brown GD; Gordon S;
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正文语种 eng
中图分类医学免疫学;
关键词
Candida albicans; Membrane Proteins; Nerve Tissue Proteins; 念珠菌; 白色; 膜蛋白质类; 神经组织蛋白质类;

机译：Candida albicans;Membrane Proteins;Nerve Tissue Proteins;念珠菌;白色;膜蛋白质类;神经组织蛋白质类;

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1. Dectin-1 escape by fungal dimorphism. [J] . Heinsbroek SE, Brown GD, Gordon S Trends in immunology . 2005,第7期

机译：Dectin-1通过真菌二态性逃逸。
2. Differential susceptibility of Dectin-1 isoforms to functional inactivation by neutrophil and fungal proteases [J] . James S. Griffiths, Aiysha Thompson, Matthew Stott, The FASEB Journal . 2018,第6期

机译：Dectin-1亚型对嗜中性粒细胞和真菌蛋白酶功能性失活的敏感性
3. Human primary myeloid dendritic cells interact with the opportunistic fungal pathogen Aspergillus fumigatus via the C-type lectin receptor Dectin-1 [J] . Hefter Maike, Lother Jasmin, Weiss Esther, Medical mycology: official publication of the International Society for Human and Animal Mycology . 2017,第5期

机译：人原发性骨髓内突细胞通过C型凝集素受体Dectin-1与机会性真菌病原体曲霉曲霉和曲霉相互作用
4. Immunological Host Defense Mechanism and Applications of Fungal β-Glucans by Employing Dectin-1 Receptor in the Innate Immunity [C] . D.H.LEE, H.W.KIM The 7th international medicinal mushroom conference . 2013

机译：先天性免疫中使用Dectin-1受体的免疫宿主防御机制及其对真菌β-葡聚糖的应用
5. The effects of Dectin-1 stimulation by fungal beta-glucans on T cell activation by dendritic cells [D] . Hassanzadeh-Kiabi, Nargess. 2016

机译：真菌β-葡聚糖刺激对树突细胞T细胞活化的影响
6. Association of Dectin-1 and DC-SIGN gene single nucleotide polymorphisms with fungal keratitis in the northern Han Chinese population [O] . Xiaoli Qu, Chengye Che, Ang Gao, 2015

机译：北方汉族人群Dectin-1和DC-SIGN基因单核苷酸多态性与真菌性角膜炎的关系
7. Association between dectin-1 gene single nucleotide polymorphisms and fungal infection: a systemic review and meta-analysis [O] . Peiru Zhou, Yufei Xie, Zhimin Yan, 2019

机译：Dectin-1基因单核苷酸多态性和真菌感染之间的关联：系统性评论和荟萃分析

Dectin-1 escape by fungal dimorphism.

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