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Memory T cell inflation: Understanding cause and effect

机译:记忆T细胞膨胀:了解因果关系

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Typically, during viral infections, T cells encounter antigen, undergo proliferative expansion and ultimately contract into a pool of memory cells. However, after infection with cytomegalovirus, a ubiquitous β-herpesvirus, T cell populations specific for certain epitopes do not contract but instead are maintained and/or accumulate at high frequencies with a characteristic effector-memory phenotype. This feature has also been noted after other infections, for example, by parvoviruses. We discuss this so-called memory T cell inflation and the factors involved in this phenomenon. Also, we consider the potential therapeutic use of memory T cell inflation as a vaccine strategy and the associated implications for immune senescence.
机译:典型地,在病毒感染期间,T细胞遇到抗原,经历增殖性扩增并最终收缩成记忆细胞池。但是,在感染了巨细胞病毒(一种普遍存在的β疱疹病毒)后,对某些表位特异的T细胞群体没有收缩,而是以具有特征性效应子记忆表型的高频率维持和/或积累。在其他感染(例如细小病毒)感染后,也注意到了此功能。我们讨论了这种所谓的记忆T细胞膨胀和这种现象所涉及的因素。此外,我们考虑了记忆T细胞膨胀作为疫苗策略的潜在治疗用途以及对免疫衰老的相关影响。

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