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首页> 外文期刊>Trends in immunology >The bone marrow: a nest for migratory memory T cells.
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The bone marrow: a nest for migratory memory T cells.

机译：骨髓：用于迁徙记忆T细胞的巢。

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摘要

It has been known for a long time that T-cell precursors generated in the bone marrow migrate to the thymus, where T-cell development occurs. However, a fact often neglected is that, under physiological conditions, mature CD4 and CD8 lymphocytes undergo extensive migration from the blood to the bone marrow and vice versa. Here, we first review several observations showing that the bone marrow can function as a secondary lymphoid organ for both CD4 and CD8 cells, as well as a preferential homing site for memory T cells. Second, we discuss evidence that, a long time after priming, memory CD8 cells proliferate more extensively in the bone marrow than they do in either secondary lymphoid or extra-lymphoid organs. Finally, we propose that the bone marrow is a central organ in mature T-cell traffic and contributes greatly to long-term cytotoxic memory, which has implications for adoptive immunotherapy and vaccine design.
机译：长期以来，已知在骨髓中产生的T细胞前体迁移到胸腺，在胸腺发生T细胞发育。但是，经常被忽略的事实是，在生理条件下，成熟的CD4和CD8淋巴细胞会从血液向骨髓大量迁移，反之亦然。在这里，我们首先回顾一些观察结果，这些结果表明骨髓既可以充当CD4和CD8细胞的次要淋巴器官，又可以充当记忆T细胞的优先归巢位点。其次，我们讨论了证据，即在启动后很长一段时间内，记忆CD8细胞在骨髓中的增殖要比在继发性淋巴或淋巴外器官中的增殖更为广泛。最后，我们提出，骨髓是成熟T细胞运输中的中心器官，并且对长期的细胞毒性记忆有很大贡献，这对过继免疫疗法和疫苗设计具有重要意义。

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