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首页> 外文期刊>Biological Psychology >The effects of depressive symptoms on cardiovascular and catecholamine responses to the induction of depressive mood.
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The effects of depressive symptoms on cardiovascular and catecholamine responses to the induction of depressive mood.

机译：抑郁症状对心血管和儿茶酚胺对诱导抑郁情绪的反应的影响。

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We examined the effects of depressive symptoms on cardiovascular and catecholamine responses to the induction of different mood states. Fifty-five healthy men and women (mean age 23.4 +/- 3 years) were recruited. Depressive symptoms were evaluated using the Center for Epidemiological Studies Depression Scale (CES-D) and participants were classified into high depressive (CES-D*16) or low depressive symptoms (CES-D < 16) groups. Following a baseline period, participants were required to complete two separate speech tasks where they were asked to recall life events that made them feel angry or depressed. The tasks were separated by a 30-min recovery period and the order was randomised between participants using a counterbalanced design. Cardiovascular function was monitored continuously using a Finometer device and saliva was collected for the assessment of 3-methoxy-phenylglycol (MHPG, the major metabolite of norephinephrine). Blood pressure (BP), heart rate, and total peripheral resistance (TPR) were significantly increased in response to both tasks (p .001). Averaged over conditions, higher diastolic BP and higher MHPG levels were observed in high depressive symptoms participants. MHPG levels did not change in response to mood induction in the low depressive symptoms group. However, the high depression symptoms group showed significantly higher levels of MHPG during recovery from the depressed mood induction task and increased levels immediately after the anger induction task. These findings suggest depressive symptoms are associated with heightened central adrenergic activation during negative mood induction, but that the time course of responses is dependent on the type of emotion elicited.
机译：我们研究了抑郁症状对诱导不同情绪状态的心血管和儿茶酚胺反应的影响。招募了55名健康的男性和女性（平均年龄23.4 +/- 3岁）。使用流行病学研究中心抑郁量表（CES-D）评估抑郁症状，并将参与者分为高抑郁症状（CES-D * 16）或低抑郁症状（CES-D <16）组。在基线期之后，要求参与者完成两个单独的语音任务，要求他们回忆使他们感到生气或沮丧的生活事件。任务间隔30分钟的恢复期，并使用平衡设计将参与者之间的顺序随机化。使用Finometer设备连续监测心血管功能，并收集唾液以评估3-甲氧基-苯基乙二醇（MHPG，去甲肾上腺素的主要代谢产物）。两项任务均使血压（BP），心率和总外周阻力（TPR）显着增加（p .001）。在高水平症状参与者中平均观察到较高的舒张压和较高的MHPG水平。在低抑郁症状组中，MHPG水平未因情绪诱导而改变。但是，高抑郁症状组在情绪低落诱导任务恢复期间表现出明显较高的MHPG水平，而在愤怒诱导任务后立即升高。这些发现表明，抑郁症状与负性情绪诱导过程中中央肾上腺素能激活增强有关，但反应的时间长短取决于引起的情绪类型。

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