Response from Lower

Roswitha Lower

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Response from Lower

机译：下层的回应

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The issue of whether or not endogenous retroviruses (ERVs) are markers or triggers in any human disease remains controversial. Although no recent retrotransposition event has been described, the detection of a functional human ERV (HERV-K) reverse transcriptase indicates that some HERVs have retained the potential for retrotransposition. This is confirmed by the fact that integration sites are present only in the human lineage and, more convincingly, by the polymorphisms in the solitary long terminal repeats (LTRs) that are present or absent in the major histocompatability complex (MHC) haplotypes. There is evidence that these polymorphisms might predispose individuals towards certain diseases.

机译：内源性逆转录病毒（ERVs）是否是任何人类疾病的标志或触发因素仍存在争议。尽管没有描述最近的逆转座事件，但检测到功能性人ERV（HERV-K）逆转录酶表明某些HERV保留了逆转座的潜力。整合位点仅存在于人类谱系中，更令人信服的是，主要组织相容性复合体（MHC）单倍型中存在或不存在的孤立长末端重复序列（LTR）多态性证实了这一点。有证据表明，这些多态性可能使个体容易患某些疾病。

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来源
《Trends in Microbiology》 |1999年第11期|共2页
作者
Roswitha Lower;
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正文语种 eng
中图分类微生物学;
关键词
endogenous retroviruses (ERVs); long terminal repeats (LTRs); major histocompatability complex (MHC);

机译：内源性逆转录病毒（ERV）;长末端重复序列（LTR）;主要组织相容性复合体（MHC）;

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Response from Lower

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