Gastric cell apoptosis and H. pylori: has the main function of VacA finally been identified

Patrice Boquet; Vittorio Ricci; Antoine Galmiche; Nils C. Gauthier

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Gastric cell apoptosis and H. pylori: has the main function of VacA finally been identified

机译：胃细胞凋亡与幽门螺杆菌：具有VacA的主要功能最终被鉴定

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The vacuolating cytotoxin VacA is one of the most important virulence factors of Helicobacter pylori, a bacterium causing severe gastric diseases such as ulcers and cancer. VacA forms large cytoplasmic vacuoles in cultured cells, although its effects on host cells in vivo remain to be elucidated. Three independent groups have reported that VacA induces epithelial cell apoptosis. In particular, a recent study has demonstrated unambiguously the role of VacA in inducing epithelial gastric cell apoptosis.

机译：空泡细胞毒素VacA是幽门螺杆菌（Helicobacter pylori）最重要的毒力因子之一，幽门螺杆菌可引起严重的胃部疾病，如溃疡和癌症。 VacA在培养的细胞中形成大的细胞质液泡，尽管它对体内宿主细胞的作用尚待阐明。三个独立的小组报告说，VacA诱导上皮细胞凋亡。特别地，最近的研究已明确证明VacA在诱导上皮胃细胞凋亡中的作用。

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《Trends in Microbiology》 |2003年第9期|共4页
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Patrice Boquet; Vittorio Ricci; Antoine Galmiche; Nils C. Gauthier;
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1. Gastric cell apoptosis and H. pylori: has the main function of VacA finally been identified [J] . Patrice Boquet, Vittorio Ricci, Antoine Galmiche, Trends in Microbiology . 2003,第9期

机译：胃细胞凋亡与幽门螺杆菌：具有VacA的主要功能最终被鉴定
2. Helicobacter pylori VacA reduces the cellular expression of STAT3 and pro-survival Bcl-2 family proteins, Bcl-2 and Bcl-XL, leading to apoptosis in gastric epithelial cells. [J] . Matsumoto A, Isomoto H, Nakayama M, Digestive Diseases and Sciences . 2011,第4期

机译：幽门螺杆菌VacA降低STAT3的细胞表达以及存活前的Bcl-2家族蛋白Bcl-2和Bcl-XL，导致胃上皮细胞凋亡。
3. Helicobacter pylori VacA Reduces the Cellular Expression of STAT3 and Pro-survival Bcl-2 Family Proteins, Bcl-2 and Bcl-X_L, Leading to Apoptosis in Gastric Epithelial Cells [J] . Ayako Matsumoto, Hajime Isomoto, Masaaki Nakayama, Digestive Diseases and Sciences . 2011,第4期

机译：幽门螺杆菌VacA降低STAT3和存活Bcl-2家族蛋白，Bcl-2和Bcl-X _{L 的细胞表达，导致胃上皮细胞凋亡}
4. Role of Proteinase-Activated Receptor-2 on Cyclooxygenase-2 Expression in H. pylori-Infected Gastric Epithelial Cells [C] . JI HYE SEO, KYUNG HWAN KIM, HYEYOUNG KIM Meeting on Cell Signaling World: Signal Transduction Pathways as Therapeutic Targets . 2007

机译：蛋白酶激活的受体2对幽门螺杆菌感染的胃上皮细胞中环氧合酶-2表达的作用
5. Comparative study of the effects of Helicobacter pylori on EGFR signaling in transformed human gastric epithelial and gastric adenocarcinoma cell lines [D] . Settles-Reaves, Beverlyn Denise 2007

机译：幽门螺杆菌对转化的人胃上皮细胞和胃腺癌细胞系中EGFR信号转导作用的比较研究
6. The effect of Helicobacter pylori infection and different H. pylori components on the proliferation and apoptosis of gastric epithelial cells and fibroblasts [O] . Weronika Gonciarz, Agnieszka Krupa, Krzysztof Hinc, 2012

机译：幽门螺杆菌感染和幽门螺杆菌不同成分对胃上皮细胞和成纤维细胞增殖和凋亡的影响
7. The effect of Helicobacter pylori infection and different H. pylori components on the proliferation and apoptosis of gastric epithelial cells and fibroblasts [O] . Weronika Gonciarz, Agnieszka Krupa, Krzysztof Hinc, 2019

机译：幽门螺杆菌感染和不同H.幽门螺杆菌组分对胃上皮细胞和成纤维细胞增殖和凋亡的影响

Gastric cell apoptosis and H. pylori: has the main function of VacA finally been identified

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