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Quorum sensing in streptococcal biofilm formation

机译:链球菌生物膜形成中的群体感应

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Bacteria in their natural ecosystems preferentially grow as polysaccharide-encased biofilms attached to surfaces. Although quorum-sensing (QS) systems directing the 'biofilm phenotype' have been extensively described in Gram-negative bacteria, there is little understanding of the importance of these systems in Gram-positive biofilm formation. Streptococci are a diverse group of Gram-positive bacteria that colonize epithelial, mucosal and tooth surfaces of humans. In several streptococci, competence-stimulating peptide (CSP)-mediated QS has been connected with competence development for genetic transformation. Recent work, especially with bacteria that inhabit the biofilm of dental plaque, has linked CSP stimuli to other cell-density adaptations, such as biofilm formation.
机译:细菌在其自然生态系统中优先生长为附着在表面的多糖包裹生物膜。尽管在革兰氏阴性细菌中已广泛描述了引导“生物膜表型”的群体感应(QS)系统,但对这些系统在革兰氏阳性生物膜形成中的重要性了解甚少。链球菌是多种革兰氏阳性细菌,它们定植在人类的上皮,粘膜和牙齿表面。在几种链球菌中,能力刺激肽(CSP)介导的QS与基因转化的能力发展有关。最近的工作,特别是与居住在牙菌斑生物膜中的细菌有关的研究,将CSP刺激与其他细胞密度适应性疾病(例如生物膜形成)联系在一起。

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