Tools to study molecular mechanisms of Aspergillus pathogenicity

Krappmann S

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Tools to study molecular mechanisms of Aspergillus pathogenicity

机译：研究曲霉菌致病性分子机制的工具

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The unique nature of Aspergillus fungi represents a challenge for scrutinizing the attributes that render these saprophytic microorganisms pathogenic or allergenic under certain environmental circumstances. Recent publication of the genomic sequence from an isolate of the major pathogen Aspergillus fumigatus denotes enormous progress in aiming at cellular features and gene products that contribute to its pathogenicity. Latest developments to study virulence-related characteristics comprise profiling techniques, conditional gene inactivation and precise manipulation of the genome by means of gene targeting. Advances in assessing the virulence potential of particular mutant strains in alternative test systems complement these approaches.

机译：曲霉真菌的独特性质代表了对在某些环境条件下使这些腐生微生物致病或致敏的特性进行审查的挑战。从主要病原体烟曲霉的分离物中获得的基因组序列的最新出版物表明，在针对有助于其致病性的细胞特征和基因产物方面取得了巨大进展。研究毒力相关特征的最新进展包括分析技术，条件性基因失活和通过基因靶向对基因组进行精确操作。在替代测试系统中评估特定突变菌株的毒力潜力的进展补充了这些方法。

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《Trends in Microbiology》 |2006年第8期|共9页
作者
Krappmann S;
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正文语种 eng
中图分类微生物学;
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Tools to study molecular mechanisms of Aspergillus pathogenicity

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