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首页> 外文期刊>Trends in Microbiology >Multiple sclerosis: an infectious syndrome involving Chlamydophila pneumoniae
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Multiple sclerosis: an infectious syndrome involving Chlamydophila pneumoniae

机译：多发性硬化症：涉及肺炎衣原体的传染性综合征

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摘要

The concept of autoimmune myelinopathy as the primary pathology in multiple sclerosis (MS) is problematic. Vasculitis is seen in the MS brain, both within lesions and in adjacent normal-appearing white matter. The first observation in acute relapse is the sudden, orderly death of oligodendrocytes; inflammatory removal of unsupported myelin seems to be a secondary process. An alternative explanation for these findings is that oligodendrocyte infection might trigger an inflammatory response. Many pathogens, including Chlamydophila (Chlamydia) pneumoniae, have been associated with MS. MS might be an infectious syndrome in which C. pneumoniae has a role in a subset of patients. Mechanisms by which such a cryptic infection could engender relapsing–remitting and, ultimately, progressive disease patterns are discussed.
机译：自身免疫性脊髓病作为多发性硬化症（MS）的主要病理学概念是有问题的。在病变脑部和邻近的正常出现的白质中均可见到MS脑血管炎。急性复发的第一个观察结果是少突胶质细胞突然死亡。炎性去除不受支持的髓磷脂似乎是继发过程。这些发现的另一种解释是少突胶质细胞感染可能引发炎症反应。许多病原体，包括肺炎衣原体（衣原体），都与MS有关。 MS可能是其中肺炎衣原体在一部分患者中起作用的传染综合征。讨论了这种隐性感染可能导致复发-缓解，最终导致进行性疾病的机制。

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