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Antimicrobials: targeting virulence genes necessary for intracellular multiplication

机译:抗菌药物:靶向细胞内增殖所必需的毒力基因

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摘要

Intracellular bacteria constitute a major class of pathogens for humans and animals. Their pathogenicity is linked to their ability to multiply inside a host cell. A set of virulence genes (virulome) is required for this intracellular lifestyle. Recent studies have shown that blocking the enzymes encoded by these virulence genes impairs intracellular multiplication of the pathogen. These specific factors could constitute a new set of possible targets for antimicrobial drugs. The potential advantages, pitfalls and challenges of a strategy that targets these virulence factors are discussed.
机译:细胞内细菌构成人类和动物的主要病原体类别。它们的致病性与其在宿主细胞内繁殖的能力有关。这种细胞内生活方式需要一组毒力基因(毒力)。最近的研究表明,阻断由这些毒力基因编码的酶会损害病原体的细胞内繁殖。这些特定因素可能构成抗菌药物的一组新的可能目标。讨论了针对这些毒力因子的策略的潜在优势,陷阱和挑战。

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