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首页> 外文期刊>Trends in Microbiology >Secreted bacterial phospholipase A2 enzymes: better living through phospholipolysis
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Secreted bacterial phospholipase A2 enzymes: better living through phospholipolysis

机译：分泌的细菌磷脂酶A2酶：通过磷脂分解改善生活

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摘要

Phospholipases are ubiquitous and diverse enzymes that induce changes in membrane composition, activate the inflammatory cascade and alter cell signaling pathways. Recent evidence suggests that certain bacterial pathogens have acquired genes encoding secreted phospholipase A2 enzymes through lateral gene transfer events. The two best-studied members of this class of enzyme are ExoU and SlaA, which are produced by Pseudomonas aeruginosa and group A Streptococcus, respectively. These enzymes modulate the host inflammatory response, increase the severity of disease and otherwise alter host–pathogen interactions. We propose that a key function of ExoU and SlaA is to increase the fitness of the subclones expressing these enzymes, thereby increasing the population size of the PLA2-positive strains and enhancing the likelihood of encountering an at-risk host.
机译：磷脂酶是普遍存在的多种酶，可诱导膜组成发生变化，激活炎症级联反应并改变细胞信号传导途径。最近的证据表明，某些细菌病原体已通过侧向基因转移事件获得了编码分泌型磷脂酶A2酶的基因。这类酶的两个研究最好的成员是ExoU和SlaA，它们分别由铜绿假单胞菌和A组链球菌产生。这些酶调节宿主的炎症反应，增加疾病的严重程度，并改变宿主与病原体的相互作用。我们提出ExoU和SlaA的关键功能是增加表达这些酶的亚克隆的适应性，从而增加PLA2阳性菌株的种群规模，并增加遇到高风险宿主的可能性。

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