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Offering surprises: TCA cycle regulation in Corynebacterium glutamicum

机译:令人惊讶的是:谷氨酸棒杆菌中的TCA周期调控

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摘要

Corynebacterium glutamicum, a Gram-positive soil bacterium, is used for the production of l-glutamate and l-lysine, both of which are derived from intermediates of the tricarboxylic acid (TCA) cycle. Recent studies have revealed that this amphibolic pathway is subject to complex regulation not only at the transcriptional level, but also at the post-transcriptional level. The latter involves serine/threonine protein kinase G and its target protein OdhI. Depending on its phosphorylation state, OdhI inhibits the 2-oxoglutarate dehydrogenase complex. This new type of TCA cycle control will be reviewed here together with regulation at the level of gene expression.
机译:谷氨酸棒杆菌是革兰氏阳性土壤细菌,用于生产l-谷氨酸和l-赖氨酸,两者均源自三羧酸(TCA)循环的中间体。最近的研究表明,这种两性途径不仅在转录水平而且在转录后水平都受到复杂的调节。后者涉及丝氨酸/苏氨酸蛋白激酶G及其靶蛋白OdhI。根据其磷酸化状态,OdhI抑制2-氧戊二酸脱氢酶复合物。本文将对这种新型的TCA周期控制以及基因表达水平的调控进行综述。

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