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The benefits of using diverse animal models for studying pertussis

机译:使用多种动物模型研究百日咳的好处

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Pertussis, a respiratory disease caused by infection with Bordetella pertussis, represents one of the most devastating diseases in infants and young children worldwide. Significant research efforts over the last five decades have led to the introduction of two types of vaccines, which are now available worldwide and which have significantly reduced the global incidence of pertussis. The use of animal models and, in particular, the mouse model has benefited in the development of these vaccines tremendously. However, open questions regarding the duration of immunity, the type of immune response needed for protection and the role of mucosal and innate immunity in disease protection still remain. Here, we review the various animal models available currently and their benefits for studying this important disease.
机译:百日咳是一种由百日咳博德特氏菌感染引起的呼吸道疾病,是全世界婴儿和儿童中最具破坏性的疾病之一。在过去的五十年中,大量的研究工作导致了两种疫苗的问世,这两种疫苗现已在全球范围内销售,并且大大降低了百日咳的全球发病率。使用动物模型,尤其是小鼠模型,极大地受益于这些疫苗的开发。然而,关于免疫持续时间,保护所需的免疫反应类型以及粘膜和先天免疫在疾病保护中的作用仍然存在悬而未决的问题。在这里,我们回顾了当前可用的各种动物模型及其对研究这种重要疾病的益处。

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