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首页> 外文期刊>Trends in Microbiology >Cell integrins: commonly used receptors for diverse viral pathogens
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Cell integrins: commonly used receptors for diverse viral pathogens

机译：细胞整合素：各种病毒病原体的常用受体

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摘要

When searching for their favorite host tissues, animal viruses frequently attach to cell-surface receptors that have key roles in normal cell physiology. Integrins are prime examples of physiologically important receptors that have been usurped by nonenveloped and enveloped viruses for attachment and/or cell entry. This family of heterodimeric receptors mediates cell adhesion, cell migration, tumor metastasis and cell differentiation. Recent investigations have shed new light on integrin structure as well as on the underlying molecular features of their association with viral ligands. In this review, we discuss several examples of virus–integrin interactions that highlight recent advances in this field. The continuing improvements in virus and cell imaging techniques have helped to uncover the molecular basis of how integrins are recognized by such a wide range of microbial pathogens to invade host cells.
机译：当寻找它们最喜欢的宿主组织时，动物病毒通常会附着在细胞表面受体上，这些受体在正常细胞生理中起关键作用。整联蛋白是已被非包膜和包膜病毒篡改用于附着和/或细胞进入的生理学重要受体的主要实例。该异二聚体受体家族介导细胞粘附，细胞迁移，肿瘤转移和细胞分化。最近的研究为整联蛋白的结构以及与病毒配体结合的潜在分子特征提供了新的思路。在这篇综述中，我们讨论了病毒与整合素相互作用的几个例子，这些例子突出了该领域的最新进展。病毒和细胞成像技术的不断改进已经帮助揭示了整合素如何被如此广泛的微生物病原体入侵宿主细胞的分子基础。

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