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首页> 外文期刊>Trends in Microbiology >Effector proteins translocated by Legionella pneumophila: strength in numbers
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Effector proteins translocated by Legionella pneumophila: strength in numbers

机译：嗜肺军团杆菌易位的效应蛋白：强度

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摘要

The Gram-negative bacterium Legionella pneumophila is a parasite of eukaryotic cells. It has evolved to survive and replicate in a wide range of protozoan hosts and can also infect human alveolar macrophages as an opportunistic pathogen. Crucially for the infection process, L. pneumophila uses a type IV secretion system called Dot/Icm to translocate bacterial proteins into host cells. In recent years a large number of Dot/Icm-translocated proteins have been identified. The study of these proteins, referred to as effectors, is providing valuable insight into the mechanism by which an intracellular pathogen can manipulate eukaryotic cellular processes to traffic and replicate in host cells.
机译：革兰氏阴性细菌嗜肺军团菌是真核细胞的寄生虫。它已经进化成能在多种原生动物宿主中生存和复制，并且还可以作为机会性病原体感染人肺泡巨噬细胞。对于感染过程而言，至关重要的是，嗜肺乳杆菌使用称为Dot / Icm的IV型分泌系统将细菌蛋白转移到宿主细胞中。近年来，已鉴定出大量的Dot / Icm易位蛋白。这些蛋白质的研究，称为效应子，为细胞内病原体可以操纵真核细胞过程在宿主细胞中运输和复制的机制提供了有价值的见解。

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