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Where and how do anthrax toxins exit endosomes to intoxicate host cells?

机译:炭疽毒素在何处以及如何从内体中排出来使宿主细胞中毒?

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The role of Bacillus anthracis virulence factors in its pathogenesis has been subjected to intense investigation with the aim of finding novel preventive and therapeutic protocols. Toxins that are endocytosed and act in the cytosol of host cells have a central role in B. anthracis infection. Understanding of anthrax toxin cell entry has increased during the past few years and a composite picture is emerging. Nevertheless, unanswered and controversial questions remain, particularly concerning the site and mode of anthrax toxin cell entry, the role of anthrax toxin receptors in the process and the possible involvement of cytosolic chaperones, which might affect entry efficiency. Here, the current model of anthrax toxin cell entry, an alternative model and experimental approaches for clarifying unanswered questions will be discussed.
机译:炭疽芽孢杆菌毒力因子在其发病机理中的作用已受到深入研究,目的是发现新的预防和治疗方案。被内吞并在宿主细胞的细胞质中起作用的毒素在炭疽芽孢杆菌感染中起着核心作用。在过去的几年中,人们对炭疽毒素细胞进入的了解有所增加,并且出现了综合情况。然而,仍然存在未解决和有争议的问题,特别是关于炭疽毒素细胞进入的部位和方式,炭疽毒素受体在此过程中的作用以及可能影响进入效率的胞质伴侣的可能参与。在这里,将讨论炭疽毒素细胞进入的当前模型,替代模型和澄清未解决问题的实验方法。

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