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首页> 外文期刊>Trends in Microbiology >The search for disease-associated compositional shifts in bowel bacterial communities of humans
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The search for disease-associated compositional shifts in bowel bacterial communities of humans

机译：在人类肠道细菌群落中寻找与疾病相关的成分变化

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The bowels of humans contain resident bacterial communities, the members of which are numerous and biodiverse. Changes in the composition of bowel communities is accepted to occur in relation to antibiotic-associated colitis of the elderly, but compositional alterations could also be relevant to allergic diseases in children and inflammatory bowel diseases (i.e. Crohn's disease and ulcerative colitis). It is timely, therefore, to reflect on current knowledge of the bacterial community of the human bowel in relation to disease. Modern analytical methods provide tools by which compositional shifts in bacterial communities can be detected, but inadequate bowel-sampling procedures and poorly designed studies hamper progress. Moreover, demonstration that population shifts cause the disease and are not just reflections of a diseased state is necessary. Therefore, important challenges remain for bacteriologists in investigations of the bowel bacterial community in relation to disease.
机译：人类的肠道包含常驻细菌群落，其成员众多且生物多样性。肠道菌群组成的变化被认为与老年人的抗生素相关性结肠炎有关，但是组成的改变也可能与儿童的过敏性疾病和炎性肠病（例如克罗恩氏病和溃疡性结肠炎）有关。因此，适时反思与疾病有关的人类肠道细菌群落的最新知识。现代的分析方法提供了检测细菌群落组成变化的工具，但肠道采样程序不足和研究设计不当阻碍了研究进展。此外，有必要证明人口转移会导致疾病，而不仅仅是疾病状态的反映。因此，细菌学家在与疾病相关的肠道细菌群落研究中仍然面临着重要的挑战。

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