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首页> 外文期刊>Trends in Microbiology >Cytolethal distending toxin: limited damage as a strategy to modulate cellular functions
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Cytolethal distending toxin: limited damage as a strategy to modulate cellular functions

机译：细胞致死性扩张性毒素：有限的损伤作为调节细胞功能的策略

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摘要

The coevolution of bacterial pathogens and their hosts has contributed to the development of very complex and sophisticated functional pathogen-host interfaces. Thus, well-adapted pathogens have evolved a variety of strategies to manipulate host cell functions precisely. For example, a group of unrelated Gram-negative pathogenic bacteria have evolved a toxin, known as cytolethal distending toxin (CDT), that has the ability to control cell cycle progression in eukaryotic cells. Recent studies have identified CdtB as the active subunit of the CDT holotoxin. Through its nuclease activity, CdtB causes limited DNA damage, thereby triggering the DNA-damage response that ultimately results in the observed arrest of the cell cycle. In addition, it has been established that CDT is a tripartite AB toxin in which CdtB is the active 'A' subunit and CdtA and CdtC constitute the heterodimeric 'B' subunit required for the delivery of CdtB into the target cell. The mechanism of action of CDT suggests that the infliction of limited damage could be a strategy used by pathogenic bacteria to modulate host cell functions.
机译：细菌病原体及其宿主的共同进化促进了非常复杂和复杂的功能性病原体-宿主界面的发展。因此，适应性强的病原体已经进化出多种策略来精确地操纵宿主细胞的功能。例如，一组无关的革兰氏阴性致病菌已经进化出一种毒素，称为细胞致死性扩张毒素（CDT），它具有控制真核细胞中细胞周期进程的能力。最近的研究已将CdtB确定为CDT全毒素的活性亚基。通过其核酸酶活性，CdtB导致有限的DNA损伤，从而触发DNA损伤反应，最终导致观察到的细胞周期停滞。另外，已经确定CDT是三重AB毒素，其中CdtB是活性“ A”亚基，而CdtA和CdtC构成将CdtB递送至靶细胞所需的异二聚体“ B”亚基。 CDT的作用机制表明，造成有限的损害可能是致病菌调节宿主细胞功能的一种策略。

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