Did the loss of sigma factors initiate pseudogene accumulation in M. leprae?

M. Madan Babu

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Did the loss of sigma factors initiate pseudogene accumulation in M. leprae?

机译：σ因子的丧失是否引发了麻疯树中假基因的积累？

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Pseudogenes are non-functional regions in the genome that have arisen as a consequence of accumulating mutations that either result in the premature termination of proteins during protein synthesis or the disruption of transcription. There have been various discussions of the origins of pseudogenes and the models for their formation, but there has been little input on how pseudogenes could have accumulated in an organism. In this brief communication, I propose a two-step model for the accretion of pseudogenes in the Myco-bacterium leprae genome, triggered by the loss of different sets of sigma factors at different time points during the course of evolution.

机译：伪基因是基因组中的非功能区，是由于积累突变而产生的，这些突变导致蛋白质合成过程中蛋白质过早终止或转录中断。关于假基因的起源和形成模型的讨论很多，但是关于假基因如何在生物体中积累的信息很少。在此简短的交流中，我提出了一个分两步的模型，用于在麻风分支杆菌基因组中假基因的积累，该过程由进化过程中不同时间点的不同sigma因子的丢失触发。

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《Trends in Microbiology》 |2003年第2期|共3页
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M. Madan Babu;
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1. Did the loss of sigma factors initiate pseudogene accumulation in M. leprae? [J] . M. Madan Babu Trends in Microbiology . 2003,第2期

机译：σ因子的丧失是否引发了麻疯树中假基因的积累？
2. Opposite effects of M. leprae or M. bovis BCG delipidation on cellular accumulation into mouse pleural cavity. Distinct accomplishment of mycobacterial lipids in vivo. [J] . Moura AC, Leonardo PS, Henriques MG, Inflammation research: Official journal of the European Histamine Research Society . 1999,第6期

机译：麻风分枝杆菌或牛分枝杆菌的BCG脱脂对小鼠胸膜腔内细胞积累的相反作用。分枝杆菌脂质体内的不同成就。
3. Cloning of mce1 locus of Mycobacterium leprae in Mycobacterium smegmatis mc2 155 SMR5 and evaluation of expression of mce1 genes in M. smegmatis and M. leprae. [J] . Santhosh RS, Pandian SK, Lini N, FEMS immunology and medical microbiology . 2005,第2期

机译：耻垢分枝杆菌mc2 155 SMR5中麻风分枝杆菌mce1基因座的克隆和耻垢分枝杆菌和麻风分枝杆菌中mce1基因表达的评估。
4. PHYLOGENETIC ANALYSIS OF HUMAN OLFACTORY RECEPTOR SEGREGATING PSEUDOGENES [C] . Nie Yumin, Sun Xiao The 6'th International Forum on Post-genome Technologies(6'IFPT)（第六届国际后基因组生命科学技术学术论坛） . 2009

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5. the Environmental Factors Influencing the Accumulation and Loss of the Dissolved Organic Phosphorus (DOP) in the Global Surface Ocean [D] . Liang, Zhou. 2020

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6. Ocular histopathology in animals experimentally infected with Mycobacterium leprae and M. lepraemurium. 1. Mycobacterium leprae and M. lepraemurium infections in the mouse. 2. Mycobacterium leprae infections in the 9-banded armadillo (Dasypus novemcinctus L.). [O] . H. E. Hobbs, D. J. Harman, J. W. Rees, 1978

机译：实验性感染麻风分枝杆菌和麻风分枝杆菌的动物的眼组织病理学。 1.小鼠中的麻风分枝杆菌和麻风分枝杆菌感染。 2. 9带状犰狳（Dasypus novemcinctus L.）中的麻风分枝杆菌感染。
7. Morfologia do Mycobacterium leprae hominis e do M. leprae muris: estudo baseado na microscopia electrônica e de contraste de fases Morphology of Mycobacterium leprae hominis and M. leprae muris based on electron and phases contrast microscopy [O] . H. C. de Souza-Araújo 1955

机译：人型麻风分枝杆菌和麻风杆菌的形态学：基于电子和相差显微镜的研究人类麻风分枝杆菌和麻风杆菌的形态学

Did the loss of sigma factors initiate pseudogene accumulation in M. leprae?

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