Structure and mode of action of clostridial glucosylating toxins: the ABCD model.

Jank T; Aktories K

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Structure and mode of action of clostridial glucosylating toxins: the ABCD model.

机译：梭菌糖基化毒素的结构和作用方式：ABCD模型。

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Toxins A and B, which are the major virulence factors of antibiotic-associated diarrhea and pseudomembranous colitis caused by Clostridium difficile, are the prototypes of the family of clostridial glucosylating toxins. The toxins inactivate Rho and Ras proteins by glucosylation. Recent findings on the autocatalytic processing of the toxins and analysis of the crystal structures of their domains have made a revision of the current model of their actions on the eukaryotic target cells necessary.

机译：毒素A和B是艰难梭菌引起的与抗生素相关的腹泻和假膜性结肠炎的主要毒力因子，是梭菌糖基化毒素家族的原型。毒素通过糖基化使Rho和Ras蛋白失活。毒素的自催化处理及其结构域晶体结构的最新发现使对它们对真核靶细胞作用的当前模型进行了修订。

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《Trends in Microbiology》 |2008年第5期|共8页
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Jank T; Aktories K;
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1. Structure and mode of action of clostridial glucosylating toxins: the ABCD model. [J] . Jank T, Aktories K Trends in Microbiology . 2008,第5期

机译：梭菌糖基化毒素的结构和作用方式：ABCD模型。
2. The effect of botulinum toxin type A injection on compound muscle action potential in an in vivo rat model. [J] . Cichon JV Jr, McCaffrey TV, Litchy WJ, The Laryngoscope: A Medical Journal for Clinical and Research Contributions in Otolaryngology, Head and Neck Medicine and Surgery, Facial Plastic and Reconstructive Surgery .. . 1995,第2期

机译：在体内大鼠模型中，A型肉毒毒素注射对复合肌肉动作电位的影响。
3. Crystal structure of Mycobacterium tuberculosis VapC20 toxin and its interactions with cognate antitoxin, VapB20, suggest a model for toxin-antitoxin assembly [J] . The FEBS journal . 2017,第23期

机译：结核分枝杆菌的晶体结构VAPC20毒素及其与同源抗毒素的相互作用，VAPB20，表明了毒素 - 抗毒素组件的模型
4. Rapid quantification of Clostridial Epsilon toxin by immuno-purification and Ultra-Performance Liquid Chromatography - tandem mass spectrometry [C] . Alexandre SEYER, Francois FENAILLE, Cecile FERAUDET-TARISSE, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2012

机译：免疫纯化和超高效液相色谱法快速定量梭菌ε毒素 - 串联质谱法
5. Three-dimensional computational modeling of fluid-structure interaction: Study of diastolic function in a thin-walled left heart model. [D] . Lemmon, Jack David, Jr. 1998

机译：流体-结构相互作用的三维计算模型：左心薄壁模型中舒张功能的研究。
6. Semaphorins or Frizzled –it is the receptor that direct the action of clostridial glucosylating toxins [O] . Klaus Aktories 2020

机译：信号蛋白或毛躁 - 是指导梭菌葡萄糖型毒素的作用的受体
7. Semaphorins or Frizzled –it is the receptor that direct the action of clostridial glucosylating toxins [O] . Klaus Aktories 2020

机译：信号蛋白或毛躁 - 是指导梭菌葡萄糖型毒素的作用的受体
8. Mode of Action of Shigella Toxin: Effects on Ribosome Structure and Function. [R] . Obrig, T. G. 1988

机译：志贺氏菌毒素的作用方式：对核糖体结构和功能的影响。

Structure and mode of action of clostridial glucosylating toxins: the ABCD model.

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