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首页> 外文期刊>Trends in Microbiology >Fungal LysM effectors: extinguishers of host immunity?
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Fungal LysM effectors: extinguishers of host immunity?

机译：真菌LysM效应子：宿主免疫的灭火剂？

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摘要

Lysin motifs (LysMs) have been recognized in prokaryotes and plants as carbohydrate-binding protein modules. Recently, a novel virulence factor with LysMs was characterized from the plant pathogenic fungus Cladosporium fulvum. Here, we present a survey of public sequence data of 70 fungal species to demonstrate that putatively secreted LysM-containing proteins are widespread in the fungal kingdom, as they are found in mammalian and plant pathogenic species, in addition to saprophytes. We propose that these putative LysM effectors might have a role in sequestration of chitin oligosaccharides - breakdown products of fungal cell walls that are released during invasion and act as triggers of host immunity - to dampen host defence.
机译：溶素基序（LysMs）已在原核生物和植物中被识别为碳水化合物结合蛋白模块。最近，从植物病原性真菌黄枝孢霉（Cladosporium fulvum）中鉴定了一种具有LysMs的新型毒力因子。在这里，我们提出一项对70种真菌物种的公共序列数据的调查，以证明推定分泌的含有LysM的蛋白质在真菌界广泛存在，因为它们除了腐生植物外还存在于哺乳动物和植物病原体中。我们建议这些假定的LysM效应子可能在螯合几丁质低聚糖中起作用。几丁质低聚糖是侵袭过程中释放的真菌细胞壁的分解产物，可作为宿主免疫力的触发因素，从而抑制宿主防御。

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