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Bacterial tyrosine kinases: novel targets for antibacterial therapy?

机译:细菌酪氨酸激酶:抗菌治疗的新目标?

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摘要

The resistance of pathogenic bacteria to current antibiotics has become a crucial public health problem. To combat this resistance, there is a constant need for antibacterial drugs with new modes of action on therapeutic targets. Recent data have shown that a variety of cellular processes essential for bacterial survival and virulence are regulated by the phosphorylation of certain endogenous proteins catalyzed by specific tyrosine kinases. In this article, I highlight a selection of recent findings that confirm the central role of protein tyrosine phosphorylation in the control of bacterial physiology. Based on this knowledge, potential applications in the discovery of novel antibiotics are proposed.
机译:病原菌对当前抗生素的抗性已成为关键的公共卫生问题。为了对抗这种抗性,一直需要对治疗靶具有新作用方式的抗菌药物。最近的数据表明,细菌存活和致病力所必需的多种细胞过程受特定酪氨酸激酶催化的某些内源蛋白的磷酸化作用的调节。在本文中,我重点介绍了一系列最近的发现,这些发现证实了蛋白质酪氨酸磷酸化在控制细菌生理中的核心作用。基于此知识,提出了在发现新型抗生素方面的潜在应用。

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