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Sense and sensibility: flagellum-mediated gene regulation

机译:感觉和敏感性:鞭毛介导的基因调控

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摘要

The flagellum, a rotary engine required for motility in many bacteria, plays key roles in gene expression. It has been known for some time that flagellar substructures serve as checkpoints that coordinate flagellar gene expression with assembly. Less well understood, however, are other more global effects on gene expression. For instance, the flagellum acts as a 'wetness' sensor in Salmonella typhimurium, and as a mechanosensor in other bacteria. Additionally, it has been implicated in a variety of bacterial processes, including biofilm formation, pathogenesis and symbiosis. Although for many of these processes it might be simply that motility is required, in other cases it seems that the flagellum plays an underappreciated role in regulating gene expression.
机译:鞭毛是许多细菌运动所需的旋转引擎,在基因表达中起关键作用。一段时间以来,已知鞭毛亚结构作为协调鞭毛基因表达与装配的检查点。然而,对基因表达的其他更全面的影响尚不为人所知。例如,鞭毛在鼠伤寒沙门氏菌中充当“湿度”传感器,而在其他细菌中充当机械传感器。另外,它与多种细菌过程有关,包括生物膜形成,发病机理和共生。尽管对于这些过程中的许多过程来说,可能只是需要运动性,但在其他情况下,鞭毛似乎在调节基因表达中的作用不足。

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