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首页> 外文期刊>Trends in Microbiology >Nanostructured bacterial materials for innovative medicines
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Nanostructured bacterial materials for innovative medicines

机译：用于创新药物的纳米结构细菌材料

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摘要

The development of innovative medicines and personalized biomedical approaches require the identification and implementation of new biocompatible materials produced by methodologically simple and cheap fabrication methods. The biological fabrication of materials, mostly carried out by microorganisms, has historically provided organic compounds with wide-spectrum biomedical applications, including hyaluronic acid, poly(gamma-glutamic acid) and polyhydroxyalkanoates. Additionally, the implementation of new methodological platforms such as metabolic engineering and systems biology have facilitated the controlled production of natural nanoparticles produced by bacteria, including metallic deposits of Au, Ag, Cd, Zn or Fe, virus-like particles or other nanoscale protein-only entities. The unexpected potential of such self-organized and functional materials in nanomedical scenarios (especially in drug delivery, imaging and tissue engineering) prompts serious consideration of further exploitation of bacterial cell factories as convenient alternatives to chemical synthesis and as sources of novel bioproducts that could dramatically expand the existing catalog of biomedical materials.
机译：创新药物和个性化生物医学方法的发展要求鉴定和实施通过方法学上简单且廉价的制造方法生产的新型生物相容性材料。从历史上讲，材料的生物制造主要由微生物完成，历史上已经为有机化合物提供了广谱的生物医学应用，包括透明质酸，聚（γ-谷氨酸）和聚羟基链烷酸酯。此外，新方法平台（例如代谢工程和系统生物学）的实施促进了细菌产生的天然纳米颗粒的受控生产，这些天然纳米颗粒包括金，银，镉，锌或铁的金属沉积物，病毒样颗粒或其他纳米级蛋白质，仅实体。这种自组织和功能性材料在纳米医学场景中（尤其是在药物输送，成像和组织工程中）的出乎意料的潜力促使人们认真考虑进一步利用细菌细胞工厂作为化学合成的便捷替代品和新型生物产品的来源。扩展现有的生物医学材料目录。

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