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Functional viral metagenomics and the next generation of molecular tools

机译：功能性病毒宏基因组学和下一代分子工具

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The enzymes of bacteriophages and other viruses have been essential research tools since the first days of molecular biology. However, the current repertoire of viral enzymes only hints at their overall potential. The most commonly used enzymes are derived from a surprisingly small number of cultivated viruses, which is remarkable considering the extreme abundance and diversity of viruses revealed over the past decade by metagenomic analysis. To access the treasure trove of enzymes hidden in the global virosphere and develop them for research, therapeutic and diagnostic uses, improvements. are needed in our ability to rapidly and efficiently discover, express and characterize viral genes to produce useful proteins. In this paper, we discuss improvements to sampling and cloning methods, functional and genomics-based screens, and expression systems, which should accelerate discovery of new enzymes and other viral proteins for use in research and medicine.
机译：自分子生物学诞生以来，噬菌体和其他病毒的酶一直是必不可少的研究工具。但是，当前的病毒酶库仅暗示其整体潜力。最常用的酶源自数量极少的培养病毒，考虑到过去十年通过宏基因组学分析揭示的病毒的极端丰富性和多样性，这是非常了不起的。访问隐藏在全球病毒圈中的酶的宝库，并将其开发用于研究，治疗和诊断用途以及改进。我们需要快速有效地发现，表达和表征病毒基因以产生有用蛋白质的能力。在本文中，我们讨论了对采样和克隆方法，基于功能和基因组学的筛选以及表达系统的改进，这些改进将加速发现用于研究和医学的新酶和其他病毒蛋白。

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