首页> 外文期刊>Trends in Microbiology >Revealing the dynamics of polymicrobial infections: implications for antibiotic therapy
【24h】

Revealing the dynamics of polymicrobial infections: implications for antibiotic therapy

机译:揭示微生物感染的动态:对抗生素治疗的意义

获取原文
获取原文并翻译 | 示例
           

摘要

As a new generation of culture-independent analytical strategies emerge, the amount of data on polymicrobial infections will increase dramatically. For these data to inform clinical thinking, and in turn to maximise benefits for patients, an appropriate framework for their interpretation is required. Here, we use cystic fibrosis (CF) lower airway infections as a model system to examine how conceptual and technological advances can address two clinical questions that are central to improved management of CF respiratory disease. Firstly, can markers of the microbial community be identified that predict a change in infection dynamics and clinical outcomes? Secondly, can these new strategies directly characterize the impact of antimicrobial therapies, allowing treatment efficacy to be both assessed and optimized?
机译:随着新一代与文化无关的分析策略的出现,有关微生物感染的数据量将急剧增加。为了使这些数据能指导临床思维,并进而使患者受益最大化,需要一个适当的解释框架。在这里,我们使用囊性纤维化(CF)下呼吸道感染作为模型系统,以检查概念和技术上的进步如何解决两个对改善CF呼吸系统疾病管理至关重要的临床问题。首先,是否可以鉴定出可以预测感染动态和临床结局变化的微生物群落标记?其次,这些新策略是否可以直接表征抗菌治疗的效果,从而评估和优化治疗效果?

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号